2. Others Anti-infection Apoptosis
  3. Reference Standards Bacterial Fungal Apoptosis Antibiotic
  4. Chromomycin A3 (Standard)

Chromomycin A3 (Standard)  (Synonyms: 色霉素A3 (Standard))

目录号: HY-W040129R 纯度: ≥98%
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Chromomycin A3 (Standard) 是 Chromomycin A3 (HY-W040129) 的分析标准品。本产品用于研究及分析应用。Chromomycin A3 是一种选择性结合 GC 富集 DNA 序列的抑制剂，其与 Mg2+ 形成二聚体后可靶向 DNA 小沟。Chromomycin A3 抑制 DNA 复制和转录，阻断 Sp1 转录因子与靶基因启动子结合，下调 FLIP、Mcl-1、XIAP 等抗凋亡蛋白表达，诱导肿瘤细胞 S 期周期阻滞和 caspase 依赖的凋亡 (apoptosis)。Chromomycin A3 可拮抗谷胱甘肽耗竭诱导的氧化应激以及 Camptothecin (HY-15660) 诱导的神经元凋亡。Chromomycin A3 可用于胆管癌等恶性肿瘤的基础研究，是潜在的化学增敏剂以及 GC 富集区域探针。

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Chromomycin A3 (Standard) Chemical Structure

Chromomycin A3 (Standard) Chemical Structure

CAS No. : 7059-24-7

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生物活性

Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe.

分子量

1183.25

Formula

C57H82O26
CAS 号
中文名称

色霉素A3 (Standard)
初始来源
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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Chromomycin A3 (Standard) 相关分类

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Keywords:

Chromomycin A3 (Standard)7059-24-7色霉素A3 (Standard)Reference StandardsBacterialFungalApoptosisAntibioticInhibitorinhibitorinhibit

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