2. GPCR/G Protein
  3. CRFR
  4. CP 376395 hydrochloride

CP 376395 hydrochloride 是一种有效的选择性的，可透过大脑的促肾上腺皮质激素释放因子 1 (CRF1) 受体拮抗剂。

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CP 376395 hydrochloride Chemical Structure

CP 376395 hydrochloride Chemical Structure

CAS No. : 1013933-37-3

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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CP 376395 hydrochloride 的其他形式现货产品:

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Other Forms of CP 376395 hydrochloride:

CP 376395 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist[1][2].

IC50 & Target

CRFR1

 

CRFR2

 

体外研究
(In Vitro)

CP 376395 完全拮抗大鼠大脑皮层和人 CRF1 受体中 oCRF 刺激的腺苷酸环化酶活性，表观 Ki 值为 12 nM，表明具有拮抗剂功能活性。 对人类CRF1受体亚型具有高度选择性； 对 CRF2 受体的亲和力 >10000 nM。 它对 40 种神经递质受体和离子通道的亲和力大于 1 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CP 376395 hydrochloride 相关抗体:
体内研究
(In Vivo)

CP 376395（10-20 mg/kg，腹腔注射，雄性B6小鼠）会减少 H2O 和食物摄入量，增加蔗糖摄入量，减少 EtOH 摄入量，但不会减少 EtOH 偏好[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male B6 mice (n=8-9 per group)[2]
Dosage: 0.0, 10.0, or 20.0 mg/kg
Administration: Intraperitoneally
Result: Dose-dependently attenuated intake of H2O and food, with H2O intake affected specifically during the first half of the session.
分子量

362.94

Formula

C21H31ClN2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CP 376395 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP 3763951013933-37-3CP376395CP-376395CRFRCorticotropin-releasing Factor ReceptorCRHRInhibitorinhibitorinhibit

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CP 376395 hydrochloride
目录号：
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