2. Others Stem Cell/Wnt PI3K/Akt/mTOR NF-κB Neuronal Signaling
  3. Isotope-Labeled Compounds GSK-3 NF-κB Amyloid-β
  4. Cromolyn-d5

Cromolyn-d5  (Synonyms: 色甘酸-d5; Cromoglycate-d5; Cromoglicic acid-d5; FPL-670-d5 free acid)

目录号: HY-B1619S
产品使用指南 技术支持

Cromolyn-d5 (Cromoglycate-d5) 是 Cromolyn (HY-B1619) 的氘代物。 Cromolyn (Cromoglycate) 是一种口服有效的 GSK-3β 抑制剂，IC50 为 2.0 μM。Cromolyn 也是一种肥大细胞稳定剂，能抑制肥大细胞释放介质、调节反射性支气管收缩和降低非特异性支气管高反应性，可用支气管哮喘的研究。此外，Cromolyn 还具有抗炎、抗过敏、抗组胺、抗肿瘤和神经保护等多种活性。

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Cromolyn-d<sub>5</sub> Chemical Structure

Cromolyn-d5 Chemical Structure

CAS No. : 2140317-08-2

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规格 是否有货
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Other Forms of Cromolyn-d5:

Cromolyn-d5 相关抗体

Top Publications Citing Use of Products

查看 GSK-3 亚型特异性产品:

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GSK-3 GSK-3α GSK-3β

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cromolyn-d5 (Cromoglycate-d5) is the deuterium labeled Cromolyn (HY-B1619). Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cromolyn-d5 相关抗体:
分子量

473.40

Formula

C23H11D5O11
CAS 号
非标记 CAS
中文名称

色甘酸-d5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cromolyn-d5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cromolyn-d52140317-08-2Cromoglycate-d5 Cromoglicic acid-d5FPL-670-d5色甘酸-d5Isotope-Labeled CompoundsGSK-3NF-κBAmyloid-βGlycogen synthase kinase-3Glycogen synthase kinase 3Nuclear factor-κBNuclear factor-kappaBβ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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