2. Apoptosis
  3. Apoptosis
  4. CWI1-2 hydrochloride

CWI1-2 hydrochloride 是一种 IGF2BP2 抑制剂，结合 IGF2BP2 并抑制其与 m6A 修饰的靶转录物的相互作用，可诱导细胞凋亡 (apoptosis)和分化，显示出良好的抗白血病作用。

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CWI1-2 hydrochloride Chemical Structure

CWI1-2 hydrochloride Chemical Structure

CAS No. : 2408590-37-2

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CWI1-2 hydrochloride 的其他形式现货产品:

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Other Forms of CWI1-2 hydrochloride:

CWI1-2 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1].

体外研究
(In Vitro)

CWI1-2 (0-1 μM, 24 h) hydrochloride 具有良好的抗白血病功效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CWI1-2 hydrochloride 相关抗体:

Apoptosis Analysis[1]

Cell Line: MonoMac6, MOLM13
Concentration: 0-1 μM
Incubation Time: 24 h
Result: Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells.
Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells.
Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC.
体内研究
(In Vivo)

CWI1-2（5 mg/kg，i.v.，每日一次，7-10天）hydrochloride 可显着延缓 BMT 受体 B6.SJL（CD45.1）小鼠白血病的发生和存活时间，体重无明显影响 [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

556.23

Formula

C22H18Cl4N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CWI1-2 hydrochloride 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CWI1-22408590-37-2ApoptosisIGF2BP2m6Aapoptosisdifferentiationanti-leukemicInhibitorinhibitorinhibit

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