Cyclopropavir (Synonyms: Filociclovir; ZSM-I-62; MBX-400)

目录号: HY-16721 纯度: ≥98.0%: Data Sheet SDS COA 产品使用指南
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Cyclopropavir (Filociclovir) 是一种口服活性和广谱的抗疱疹病毒 (anti-herpesvirus) 化合物。Cyclopropavir 抑制 UL97 激酶活性。Cyclopropavir 对 HCMV、MCMV 和 HAdV6 病毒具有抗病毒活性。

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Cyclopropavir Chemical Structure

CAS No. : 632325-71-4

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生物活性
纯度 & 产品资料
参考文献

生物活性

Cyclopropavir (Filociclovir) is an orally active and broad-spectrum anti-herpesvirus compound. Cyclopropavir inhibits UL97 kinase activity. Cyclopropavir has antiviral activity against HCMV, MCMV, and HAdV6 viruses^[1]^[2]^[3]^[4]^[5].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
BSC-1	EC₅₀	> 100 μM Compound: 2b	Antiviral activity against Herpes simplex virus type 1 in african green monkey BSC1 cells by ELISA Antiviral activity against Herpes simplex virus type 1 in african green monkey BSC1 cells by ELISA	[PMID: 19410465]
CCRF-HSB-2	CC₅₀	> 20 μM Compound: CPV	Cytotoxicity against human HSB2 cells after 7 days by Cell-Titer Glo assay Cytotoxicity against human HSB2 cells after 7 days by Cell-Titer Glo assay	[PMID: 22607883]
Fibroblast	EC₅₀	0.46 μM Compound: 3b	Antiviral activity against Human cytomegalovirus Towne infected in human foreskin fibroblast cells by plaque reduction assay Antiviral activity against Human cytomegalovirus Towne infected in human foreskin fibroblast cells by plaque reduction assay	[PMID: 19397271]
HFF	IC₅₀	> 100 μM Compound: CPV	Antiviral activity against HSV-1 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining Antiviral activity against HSV-1 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining	[PMID: 22607883]
HFF	IC₅₀	> 100 μM Compound: CPV	Antiviral activity against HSV-2 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining Antiviral activity against HSV-2 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining	[PMID: 22607883]
HFF	IC₅₀	> 100 μM Compound: CPV	Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining	[PMID: 22607883]
HFF	CC₅₀	> 100 μM Compound: 3b	Cytotoxicity against HFF cells by neutral red uptake assay Cytotoxicity against HFF cells by neutral red uptake assay	[PMID: 19397271]
HFF	CC₅₀	> 100 μM Compound: 2b	Cytotoxicity against HFF by visual cytotoxicity assay Cytotoxicity against HFF by visual cytotoxicity assay	[PMID: 19410465]
HFF	CC₅₀	> 100 μM Compound: 3b	Cytotoxicity against HFF cells by plaque reduction assay Cytotoxicity against HFF cells by plaque reduction assay	[PMID: 19397271]
HFF	CC₅₀	> 300 μM Compound: CPV	Cytotoxicity against human HFF cells after 3 to 8 days by crystal voilet staining Cytotoxicity against human HFF cells after 3 to 8 days by crystal voilet staining	[PMID: 22607883]
HFF	CC₅₀	> 380 μM Compound: 2b	Cytotoxicity against HFF by neutral red uptake assay Cytotoxicity against HFF by neutral red uptake assay	[PMID: 19410465]
HFF	CC₅₀	> 380 μM Compound: 1a	Cytotoxic concentration against AD169 strain of human cytomegalovirus infected HFF cells of human (by neutral red uptake) Cytotoxic concentration against AD169 strain of human cytomegalovirus infected HFF cells of human (by neutral red uptake)	[PMID: 15634003]
HFF	IC₅₀	1.4 μM Compound: CPV	Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay	[PMID: 22607883]
MOLT-3	CC₅₀	> 20 μM Compound: CPV	Cytotoxicity against human MOLT3 cells after 7 days by Cell-Titer Glo assay Cytotoxicity against human MOLT3 cells after 7 days by Cell-Titer Glo assay	[PMID: 22607883]
MOLT-3	IC₅₀	8 μM Compound: CPV	Antiviral activity against HHV-6B infected in human Molt3 cells assessed as reduction in viral DNA after 7 days by hybridization assay Antiviral activity against HHV-6B infected in human Molt3 cells assessed as reduction in viral DNA after 7 days by hybridization assay	[PMID: 22607883]
WI-38	CC₅₀	> 100 μM Compound: Cyclopropavir	Cytotoxicity against human WI38 cells by neutral red assay Cytotoxicity against human WI38 cells by neutral red assay	[PMID: 18285481]
WI-38	EC₅₀	> 100 μM Compound: Cyclopropavir	Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis	[PMID: 18285481]

体外研究
(In Vitro)

Cyclopropavir 在人包皮成纤维细胞 (HFF) 和小鼠胚胎成纤维细胞 (MEF) 中表现出抗 HCMV 病毒活性^[1]。
Cyclopropavir (15 µM) 可抑制转染 UL97 和 pp65-GFP 融合蛋白的 COS7 细胞中的 UL97 激酶活性，表现为核聚集体形成增加^[2]。
Cyclopropavir (2.5 µM；5 天) 在感染 HCMV 的人包皮成纤维细胞 (HFF) 中的半衰期比 Ganciclovir (HY-13637) 短^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cyclopropavir (1-10 mg/kg；口服；每日一次，5-28 天) 可降低感染 MCMV 的 BALB/c 小鼠和严重联合免疫缺陷症 (SCID) 小鼠的死亡率和病毒滴度^[4]。
Cyclopropavir (10-30 mg/kg；口服) 可防止免疫抑制的叙利亚仓鼠因静脉或鼻腔感染 HAdV6 而死亡，减轻肝/肺病理，并减少病毒复制^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

263.26

同用名

Filociclovir; ZSM-I-62; MBX-400

Formula

C₁₁H₁₃N₅O₃

CAS 号

632325-71-4

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 33.33 mg/mL (126.60 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7985 mL	18.9926 mL	37.9853 mL
5 mM	0.7597 mL	3.7985 mL	7.5971 mL
10 mM	0.3799 mL	1.8993 mL	3.7985 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: ≥98.0%

选择批次：

Data Sheet (615 KB) SDS (252 KB)

COA (287 KB) HNMR (261 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Kern ER, et al. In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication. Antimicrob Agents Chemother. 2005 Mar;49(3):1039-45. [Content Brief]

[2]. James SH, et al. Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase. Antimicrob Agents Chemother. 2011 Oct;55(10):4682-91. [Content Brief]

[3]. Gentry BG, et al. Metabolism of cyclopropavir and ganciclovir in human cytomegalovirus-infected cells. Antimicrob Agents Chemother. 2014;58(4):2329-33. [Content Brief]

[4]. Kern ER, et al. Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections. Antimicrob Agents Chemother. 2004 Dec;48(12):4745-53. [Content Brief]

[5]. Toth K, et al. Filociclovir Is a Potent In Vitro and In Vivo Inhibitor of Human Adenoviruses. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01299-20. [Content Brief]

Cyclopropavir 相关分类

Infection

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7985 mL	18.9926 mL	37.9853 mL	94.9632 mL
	5 mM	0.7597 mL	3.7985 mL	7.5971 mL	18.9926 mL
	10 mM	0.3799 mL	1.8993 mL	3.7985 mL	9.4963 mL
	15 mM	0.2532 mL	1.2662 mL	2.5324 mL	6.3309 mL
	20 mM	0.1899 mL	0.9496 mL	1.8993 mL	4.7482 mL
	25 mM	0.1519 mL	0.7597 mL	1.5194 mL	3.7985 mL
	30 mM	0.1266 mL	0.6331 mL	1.2662 mL	3.1654 mL
	40 mM	0.0950 mL	0.4748 mL	0.9496 mL	2.3741 mL
	50 mM	0.0760 mL	0.3799 mL	0.7597 mL	1.8993 mL
	60 mM	0.0633 mL	0.3165 mL	0.6331 mL	1.5827 mL
	80 mM	0.0475 mL	0.2374 mL	0.4748 mL	1.1870 mL
	100 mM	0.0380 mL	0.1899 mL	0.3799 mL	0.9496 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclopropavir632325-71-4Filociclovir ZSM-I-62 MBX-400MBX400MBX 400MBX-400CMVCytomegalovirusBALB/cSCIDhamstersCOS7HFFsHCMVInhibitorinhibitorinhibit

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Cyclopropavir (Synonyms: Filociclovir; ZSM-I-62; MBX-400)

Customer Review

Cyclopropavir 相关抗体

Cyclopropavir 相关产品

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•同靶点产品:

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生物活性

纯度 & 产品资料

参考文献

Cyclopropavir 相关抗体:

摩尔计算器

稀释计算器

Cyclopropavir 相关分类

完整储备液配制表

Keywords:

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