2. Anti-infection
  3. Fungal
  4. CYP51-IN-22

CYP51-IN-22 是一种强效且广谱的 CYP51 抑制剂，系 CYP51-IN-23-d3 (HY-174353S) 的非氘代物，对烟曲菌的 MIC80 为 1 μg/mL。CYP51-IN-22 具有抗耐药活性和杀菌活性，对细胞表现出良好的安全性，对小鼠表现出显著的药效学活性。CYP51-IN-22 可用于侵袭性真菌感染 (IFIs) 的研究。

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CYP51-IN-22 Chemical Structure

CYP51-IN-22 Chemical Structure

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CYP51-IN-22 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CYP51-IN-22 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum . CYP51-IN-22 is the non-deuterated form of CYP51-IN-23-d3 (HY-174353S). CYP51-IN-22 can prevent fungal phase transformation and biofilm formation. CYP51-IN-22 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-22 can be used for the study of invasive fungal infections (IFIs)[1].

体外研究
(In Vitro)

CYP51-IN-22 (Compound V23) (1-16 ml, 48 h) 对 8 种氟康唑耐药的真菌表现出广谱活性，其 MIC80 为 1-16 μg/ml[1]。
CYP51-IN-22 (2-8×MIC, 0-24 h) 以剂量依赖的方式对近平滑念珠菌 (C. parapsilosis) 表现出杀菌活性：作用时间越长、浓度越高，杀菌效果越好[1]。
CYP51-IN-22 (0-32 ml, 6 h) 在光滑念菌属 (C. glabrata) 和新型隐球菌 (C. neoformans) 的生物膜生长阶段显示出有效的抗生物膜抑制活性[1]。
CYP51-IN-22 (2-8 ml, 4 h) 能够抑制白色念珠菌 (C. albicans) 的相变[1]。
CYP51-IN-22 (10 μM, 4 h) 对 HUVEC (人脐静脉内皮细胞系) 和 SH-SY5Y (神经母细胞瘤细胞系) 的毒性可忽略不计[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CYP51-IN-22 相关抗体:
体内研究
(In Vivo)

CYP51-IN-22 (Compound V23) (10 mg/kg, i.p., 感染 4h 后注射) 在的侵袭性念珠菌病小鼠模型中，其药物疗效评估结果最为出色[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Candida parapsilosis was injected through the tail vein to establish a mouse (ICR, 4-6 weeks) candida-infection model
Dosage: 5 mg/kg, 10 mg/kg
Administration: intraperitoneal injection (i.p.) or gavage (p.o.) 4 h after infection
Result: Reduced the renal fungal load in mice and was better than the positive control fluconazole.
Dose-dependent, and the efficacy of intraperitoneal injection was better than that of oral gavage administration.
分子量

626.50

Formula

C29H30BrF2N7O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CYP51-IN-22 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP51-IN-22FungalTetrazoleAntifungal activityDrug-resistantIn vivo pharmacodynamicsInhibitorinhibitorinhibit

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目录号：
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