2. Others Protein Tyrosine Kinase/RTK Autophagy Apoptosis
  3. Reference Standards Bcr-Abl Src Autophagy Apoptosis
  4. Dasatinib hydrochloride (Standard)

Dasatinib hydrochloride (Standard)  (Synonyms: 达沙替尼盐酸盐 (Standard); BMS-354825 hydrochloride (Standard))

目录号: HY-10181AR 纯度: ≥98%
产品使用指南 技术支持

Dasatinib (hydrochloride) (Standard)是 Dasatinib (hydrochloride) 的分析标准品。本产品用于研究及分析应用。Dasatinib (BMS-354825) hydrochloride 是一种具有口服活性的，ATP 竞争性的，双重 Src/Bcr-Abl 抑制剂，具有有效的抗肿瘤活性。对 Src 和 Bcr-Abl 的 Ki 值分别为 16 pM 和 30 pM。Dasatinib hydrochloride 抑制 Bcr-Abl 和 Src 的IC50 分别为 <1.0 nM 和 0.5 nM。Dasatinib hydrochloride 还诱导凋亡 (apoptosis) 和自噬 (autophagy)。

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Dasatinib hydrochloride (Standard) Chemical Structure

Dasatinib hydrochloride (Standard) Chemical Structure

CAS No. : 854001-07-3

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生物活性

Dasatinib (hydrochloride) (Standard) is the analytical standard of Dasatinib (hydrochloride). This product is intended for research and analytical applications. Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib hydrochloride also induces apoptosis and autophagy.

分子量

524.47

同用名

达沙替尼盐酸盐 (Standard); BMS-354825 hydrochloride (Standard)

Formula

C22H27Cl2N7O2S
CAS 号
中文名称

达沙替尼盐酸盐 (Standard)；盐酸达沙替尼 (Standard)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Dasatinib hydrochloride (Standard) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dasatinib hydrochloride (Standard)854001-07-3BMS-354825 hydrochloride (Standard)达沙替尼盐酸盐 (Standard)盐酸达沙替尼 (Standard)Reference StandardsBcr-AblSrcAutophagyApoptosisorallyactiveantitumorantiproliferativeK562CMLPC3prostateMDA-MB-231breastWiDrcolonInhibitorinhibitorinhibit

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