Dexamethasone (Water Soluble)  (Synonyms: 地塞米松水溶性; Dexamethasone cyclodextrin complex)

Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone (HY-14648). Dexamethasone is a glucocorticoid receptor agonist, apoptosis inducer, and a common disease inducer in experimental animals. It can be used to construct models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has the potential to be used in COVID-19 research^[1].(Sale size is the weight of dexamethasone)

注意事项：
每克产品约含 65 mg 地塞米松 (Dexamethasone)，剩余的部分含有 β-环糊精。H2O 中的溶解度 : ≥ 100 mg/mL 指 100 mg 称重产品总量 (非有效重量) 溶于 1 mL 水。

Dexamethasone (Hexadecadrol) 调节多种转录因子，包括激活蛋白-1、核因子-AT 和核因子-kB，从而激活和抑制参与炎症反应的关键基因^[1]。
Dexamethasone 有效抑制 A549 细胞释放粒细胞-巨噬细胞集落刺激因子 (GM-CSF)，EC₅₀ 为 2.2 nM。Dexamethasone (EC₅₀=36 nM) 诱导 β₂ 受体的转录被发现与糖皮质激素受体 (GR) DNA 结合相关，发生率高 10-100 倍浓度高于抑制 GM-CSF 释放。Dexamethasone (IC₅₀=0.5 nM) 抑制 3×κB (NF-κB、IκBα 和 I-κBβ)，这与抑制 GM-CSF 释放有关^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

地塞米松水溶性; Dexamethasone cyclodextrin complex

50-02-2

固体

Off-white to light yellow

地塞米松水溶性

Room temperature in continental US; may vary elsewhere.

• [1]. LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22.  [Content Brief]

  [2]. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11  [Content Brief]

  [3]. Ballabh P, et al. Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids. Arch Dis Child Fetal Neonatal Ed. 2004 Jan;89(1):F76-83.  [Content Brief]

  [4]. Yun Chen, et al. Glucocorticoids inhibit production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Int J Clin Exp Pathol 2018;11(7):3391-3397.

  [5]. Yoshioka Y, et al. Glabridin inhibits dexamethasone-induced muscle atrophy. Arch Biochem Biophys. 2019 Mar 30;664:157-166.  [Content Brief]

  [6]. Troncoso R, et al. Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance. Cell Cycle. 2014;13(14):2281-95.  [Content Brief]

  [7]. Ong SL, et al. Hemodynamics of dexamethasone-induced hypertension in the rat. Hypertens Res. 2009 Oct;32(10):889-94.  [Content Brief]

  [8]. Nakamoto H, et al. Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs. Clin Exp Hypertens A. 1991;13(4):587-606.  [Content Brief]

  [9]. Mesripour A, et al. The effect of vitamin B6 on dexamethasone-induced depression in mice model of despair. Nutr Neurosci. 2019 Oct;22(10):744-749.  [Content Brief]

  [10]. Bhatt S, et al. Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats. Basic Clin Pharmacol Toxicol. 2016 Jul;119(1):10-8.  [Content Brief]

  [11]. Song D, et al. Physiologically Based Pharmacokinetics of Dexamethasone in Rats. Drug Metab Dispos. 2020 Sep;48(9):811-818.  [Content Brief]