1. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  2. Drug-Linker Conjugates for ADC Microtubule/Tubulin
  3. DM4-SPDP

DM4-SPDP 是由 linker SPDP 和 毒性分子 DM4 连接而成的,可用来制备抗体偶联活性分子。DM4 是抑制细胞分裂的抗微管蛋剂。SPDP 是一种短链交联剂,可通过 NHS-酯和吡啶基二硫醇反应性基团与半胱氨酸巯基形成可降解 (cleavable) 的 (可还原的) 二硫键,实现胺与巯基的结合。

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DM4-SPDP Chemical Structure

DM4-SPDP Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DM4-SPDP is a agent-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody agent conjugate[1]. SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].

IC50 & Target[1]

Maytansinoids

 

分子量

981.57

Formula

C45H61ClN4O14S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
DM4-SPDP
目录号:
HY-126493
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