1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Apoptosis
  2. EGFR Raf Apoptosis
  3. EGFR/BRAFV600E-IN-1

EGFR/BRAFV600E-IN-1 (Compound 23) 是一种有效的 EGFRBRAFV600E 双重抑制剂,IC50 分别为 0.08 和 0.15 µM。EGFR/BRAFV600E-IN-1 在 G1 前和 G2/M 期均诱导细胞凋亡 (apoptosis) 和细胞周期停滞。EGFR/BRAFV600E-IN-1 对 A-549、MCF-7、Panc-1、HT-29 具有抗增殖活性,IC50 分别为 1.2、0.79、1.3 和 1.23 µM。

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EGFR/BRAFV600E-IN-1 Chemical Structure

EGFR/BRAFV600E-IN-1 Chemical Structure

CAS No. : 2492429-45-3

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生物活性

EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAFV600E dual inhibitor with IC50s of 0.08 and 0.15 µM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, Panc-1, HT-29 with IC50s of 1.2, 0.79, 1.3, and 1.23 µM, respectively[1].

分子量

437.92

Formula

C24H24ClN3O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
EGFR/BRAFV600E-IN-1
目录号:
HY-147825
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