2. GPCR/G Protein
  3. Mas-related G-protein-coupled Receptor (MRGPR)
  4. EP-3945

EP-3945 是 Mas 相关 G 蛋白偶联受体 (MRGPR) 的激动剂，效力强过 MRGPRD 小分子激动剂 β-Alanine (HY-N0230)。MRGPR 在炎症瘙痒和疼痛感觉中起重要作用。同时，MRGPR 会结合 Gq (MRGPRX2、MRGPRX4、MRGPRX1 与 Gq 耦合；MRGPRX2、MRGPRD 与 Gi 耦合)，测得 EP-3945 对 Gq 的 EC50 为 211.6 nM。

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EP-3945 Chemical Structure

EP-3945 Chemical Structure

CAS No. : 3057176-00-5

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EP-3945 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EP-3945 is a potent agonist of Mas-related G protein-coupled receptor (MRGPR), more effective than the MRGPRD small molecule agonist β-Alanine (HY-N0230). MRGPR plays a crucial role in inflammatory pruritus and pain sensation. Additionally, MRGPR binds to Gq (MRGPRX2, MRGPRX4, MRGPRX1 couple with Gq; MRGPRX2, MRGPRD couple with Gi), with EP-3945 measured EC50 for Gq being 211.6 nM[1].

IC50 & Target

MRGPR[1]
分子量

418.49

Formula

C24H26N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EP-3945 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EP-39453057176-00-5EP3945EP 3945Mas-related G-protein-coupled Receptor (MRGPR)Inhibitorinhibitorinhibit

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目录号：
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