2. Others Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Autophagy Apoptosis
  3. Reference Standards HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) NO Synthase Autophagy Apoptosis
  4. Ethyl 3,4-dihydroxybenzoate (Standard)

Ethyl 3,4-dihydroxybenzoate (Standard)  (Synonyms: Protocatechuic acid ethyl ester (Standard))

目录号: HY-W016409R 纯度: ≥98%
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Ethyl 3,4-dihydroxybenzoate (Standard) (Protocatechuic acid ethyl ester (Standard)) 是 Ethyl 3,4-dihydroxybenzoate (HY-W016409) 的分析标准品。本产品用于研究及分析应用。Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) 是一种口服有效、可透过血脑屏障、竞争性的脯氨酰羟化酶 (PHD) 抑制剂，抑制 PHD 对缺氧诱导因子 (HIF) 的羟基化修饰。Ethyl 3,4-dihydroxybenzoate 通过抑制 PHD 稳定 HIF-1α 蛋白，激活下游通路诱导肿瘤细胞自噬 (autophagy) 和凋亡 (apoptosis)，同时调节炎症反应，抑制 NF-κB 通路、改善血管通透性及促进成骨细胞分化。Ethyl 3,4-dihydroxybenzoate 具有抗肿瘤、抗缺氧损伤及调节骨代谢作用，还可用于心血管保护 (如减轻心肌缺血损伤)、骨组织工程 (促进成骨/抑制破骨分化) 及高原脑水肿防治等领域的研究。

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Ethyl 3,4-dihydroxybenzoate (Standard) Chemical Structure

Ethyl 3,4-dihydroxybenzoate (Standard) Chemical Structure

CAS No. : 3943-89-3

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规格 价格 是否有货 数量
10 mg ￥250
3 - 5 周
25 mg ￥440
3 - 5 周
50 mg ￥660
3 - 5 周
100 mg ￥1000
3 - 5 周
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

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生物活性

Ethyl 3,4-dihydroxybenzoate (Standard) (Protocatechuic acid ethyl ester (Standard)) is the analytical standard of Ethyl 3,4-dihydroxybenzoate (HY-W016409). This product is intended for research and analytical applications. Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema.

分子量

182.18

同用名

Protocatechuic acid ethyl ester (Standard)

Formula

C9H10O4
CAS 号
中文名称

原儿茶酸乙酯 (Standard)
结构分类
初始来源
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Ethyl 3,4-dihydroxybenzoate (Standard) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethyl 3,4-dihydroxybenzoate (Standard)3943-89-3Protocatechuic acid ethyl ester (Standard)原儿茶酸乙酯 (Standard)Reference StandardsHIF/HIF Prolyl-HydroxylaseReactive Oxygen Species (ROS)NO SynthaseAutophagyApoptosisHypoxia-inducible factorsHIFsHIF-PHNitric oxide synthasesNOSprolyl-hydroxylaseantioxidantmitochondrialROScollagenInhibitorinhibitorinhibit

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