1. Cell Cycle/DNA Damage
  2. CDK
  3. FMF-04-159-2

FMF-04-159-2 

目录号: HY-127104
产品使用指南

FMF-04-159-2 是一种有效的共价 CDK14 抑制剂。FMF-04-159-2 抑制 CDK14 和 CDK2,在 NanoBRET 试验中 IC50 分别为 39.6 nM 和 256 nM。

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FMF-04-159-2 Chemical Structure

FMF-04-159-2 Chemical Structure

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Description

FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively[1].

IC50 & Target[1]

CDK14/Cyclin Y

39.6 nM (IC50, in NanoBRET assay)

CDK2

256 nM (IC50, in NanoBRET assay)

In Vitro

FMF-04-159-2 inhibits HCT116 proliferation with an IC50 of 1,144±190 nM[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

683.01

Formula

C₂₈H₃₀Cl₃N₇O₅S

SMILES

O=C(C1=NNC=C1NC(C2=C(Cl)C=C(Cl)C=C2Cl)=O)NC3CCN(S(=O)(C4=CC=CC(NC(/C=C/CN(C)C)=O)=C4)=O)CC3

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
FMF-04-159-2
目录号:
HY-127104
需求量:

FMF-04-159-2

Cat. No.: HY-127104