2. Metabolic Enzyme/Protease
  3. FXR
  4. FXR agonist 12

FXR agonist 12 (Compound C7) 是口服有效的 FXR 激动剂。FXR agonist 12 在HepG2 细胞中下调胆汁酸合成相关基因，上调胆汁酸转运相关基因。FXR agonist 12 改善 ANIT 诱导的胆汁淤积，在小鼠 NASH 模型中减轻肝损伤和纤维化。

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FXR agonist 12 Chemical Structure

FXR agonist 12 Chemical Structure

CAS No. : 1831862-88-4

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FXR agonist 12 相关抗体

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  • 生物活性

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生物活性

FXR agonist 12 (Compound C7) is the orally active agonist for FXR. FXR agonist 12 down-regulates bile acid synthesis-related genes, and up-regulates bile acid transport-related genes in HepG2 cells. FXR agonist 12 improves ANIT-induced cholestasis, ameliorates the liver damage and fibrosis in mouse NASH models[1].

分子量

404.63

Formula

C26H44O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FXR agonist 12 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FXR agonist 121831862-88-4FXR agonist12FXR agonist-12FXRNR1H4NASHcholestasisnon-alcoholic fatty liver diseaseorally activeInhibitorinhibitorinhibit

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