GE 2270A  (Synonyms: MDL 62879)

GE 2270A (MDL 62879) is an antibiotic. GE 2270A inhibits gram-positive bacteria and anaerobes by inhibiting protein synthesis. GE 2270A can be used for the research of infection^[1][2].

IC50: 0.4 μM (poly(U)-directed poly(Phe) synthesis)^[2]

GE 2270A (0.01-100 mg/L) inhibits poly(U)-directed poly(Phe) synthesis in cell-free systems with an IC₅₀ value of 0.12 mg/L^[1].
GE 2270A (0-0.1 mM; 10 min) is a strong inhibitor of protein biosynthesis in vitro as determined in a minimal E. coli purified system for poly(U)-directed poly(Phe) synthesis with an IC₅₀ value of 0.4 μM^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1290.52

C₅₆H₅₅N₁₅O₁₀S₆

134861-34-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Landini P, B et al. Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding antibiotics MDL 62,879 and efrotomycin. Biochem J. 1992 May 1;283 ( Pt 3)(Pt 3):649-52.  [Content Brief]

  [2]. Anborgh PH, Parmeggiani A. New antibiotic that acts specifically on the GTP-bound form of elongation factor Tu. EMBO J. 1991 Apr;10(4):779-84.  [Content Brief]