STON1 - stonin 1 Gene

中文名称：石宁 1

种属: Homo sapiens

同用名: SALF; SBLF; STN1; STNB1

关于 STON1

功能概要

细胞表面蛋白的内吞作用是由组装在质膜内表面上的复杂分子机制介导的。该基因编码 Drosophila melanogaster stoned B 蛋白的两个人类同系物之一。这种蛋白质与内吞机制的成分有关，并表现出模块化结构，包括一个 N 末端富含脯氨酸的结构域、一个与人类 stoneed B 样蛋白质特异的同源中心区域，以及一个与衔接蛋白 (AP) 复合物的 mu 亚基。将该基因通读转录到邻近的下游基因中，该基因编码 TFIIA-alpha/beta 样因子，生成转录本 (SALF) ，该转录本编码由与每个单独基因产物共享同一性的序列组成的融合蛋白。可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 10 月]

Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]