2. Gene
  3. ADPRHL1 - ADP-ribosylhydrolase like 1 Gene

ADPRHL1 - ADP-ribosylhydrolase like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADP-核糖水解酶 1

种属: Homo sapiens

同用名: ARH2

基因 ID: 113622 | 基因类型: protein coding

关于 ADPRHL1

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,399,610-113,453,488 (from NCBI)

This gene has 5 transcripts (splice variants), 158 orthologues and 1 paralogue. Biased expression in heart (RPKM 98.4) and prostate (RPKM 3.2).

功能概要

ADP-核糖基化是一种可逆的翻译后修饰，用于调节蛋白质功能。 ADP-核糖基转移酶 (参见 ART1；MIM 601625) 将 ADP-核糖从 NAD+ 转移到靶蛋白，而 ADP-核糖基水解酶 (例如 ADPRHL1) 逆转反应 (Glowacki 等人，2002 [PubMed 12070318]) 。[OMIM 提供, 2008 年 3 月]

ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008]

ADPRHL1 基因产物(5)

mRNA Protein Name
NM_001304433.1 NP_001291362.1 inactive ADP-ribosyltransferase ARH2 isoform 3
NM_001375393.1 NP_001362322.1 inactive ADP-ribosyltransferase ARH2 isoform 3
NM_001394807.1 NP_001381736.1 inactive ADP-ribosyltransferase ARH2 isoform 4
NM_138430.5 NP_612439.2 inactive ADP-ribosyltransferase ARH2 isoform 1
NM_199162.3 NP_954631.1 inactive ADP-ribosyltransferase ARH2 isoform 2

ADPRHL1 蛋白结构

ADP_ribosyl_GH

ADP_ribosyl_GH: ADP-ribosylglycohydrolase (6 - 327)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
蛋白主名 其他名称

inactive ADP-ribosyltransferase ARH2

ADP-ribosyl-hydrolase

关联疾病

疾病名称 别名
Brain Small Vessel Disease 2

Porencephaly 2

BSVD2

Gould Syndrome 2

Porencephaly 2, Formerly

Poren2, Formerly

Poren2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P4691 (Ser(PO3H2)396,404)-Tau Peptide (379-408) / 否
HY-RS00405 ADPRHL1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ADPRHL1 MGD MGI:2442168
Rattus norvegicus ADPRHL1 RGD RGD:1305641
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