Nlgn1 - neuroligin 1 Gene

种属: Rattus norvegicus

基因 ID: 116647 | 基因类型: protein coding

关于 Nlgn1

功能概要

Enables several functions, including cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and synapse organization. Acts upstream of or within synapse organization. Located in several cellular components, including Golgi apparatus; dendrite; and filopodium tip. Is active in glutamatergic synapse. Is integral component of postsynaptic specialization membrane. Biomarker of status epilepticus. Orthologous to human NLGN1 (neuroligin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn1 基因产物(1)

mRNA	Protein	Name
NM_053868.2	NP_446320.1	neuroligin-1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cell adhesion molecule binding	IPI IPI: 通过物理相互作用推断	15797875	RGD
enables identical protein binding	IPI IPI: 通过物理相互作用推断	19730411	RGD
enables neurexin family protein binding	IPI IPI: 通过物理相互作用推断	14522992	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	19730411	RGD
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	18093522	RGD
enables signaling receptor activity	IDA IDA: 通过直接分析推断	15797875	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in AMPA glutamate receptor clustering	IMP IMP: 通过突变表型推断	21940442	RGD
involved in NMDA glutamate receptor clustering	IDA IDA: 通过直接分析推断	19450252	RGD
involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: 通过直接分析推断	9325340	RGD
involved in cellular response to calcium ion	IDA IDA: 通过直接分析推断	14522992	RGD
involved in cytoskeletal matrix organization at active zone	IMP IMP: 通过突变表型推断	19628693	RGD
NOT involved in inhibitory postsynaptic potential	IDA IDA: 通过直接分析推断	17582332	RGD
involved in long-term synaptic potentiation	IMP IMP: 通过突变表型推断	23083734	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: 通过突变表型推断	25428619	RGD
involved in neuron cell-cell adhesion	IDA IDA: 通过直接分析推断	15797875	RGD
involved in neuron projection arborization	IGI IGI: 通过遗传相互作用推断	22750515	RGD
involved in neuron projection development	IGI IGI: 通过遗传相互作用推断	22750515	RGD
involved in positive regulation of dendritic spine development	IDA IDA: 通过直接分析推断	17582332	RGD
involved in positive regulation of dendritic spine development	IMP IMP: 通过突变表型推断	15681343	RGD
involved in positive regulation of excitatory postsynaptic potential	IDA IDA: 通过直接分析推断	17582332	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: 通过突变表型推断	19628693	RGD
involved in positive regulation of filopodium assembly	IDA IDA: 通过直接分析推断	12930820	RGD
involved in positive regulation of intracellular signal transduction	IDA IDA: 通过直接分析推断	17582332	RGD
involved in positive regulation of presynaptic active zone assembly	IDA IDA: 通过直接分析推断	15797875	RGD
involved in positive regulation of protein localization to synapse	IMP IMP: 通过突变表型推断	15681343	RGD
involved in positive regulation of ruffle assembly	IDA IDA: 通过直接分析推断	12930820	RGD
involved in positive regulation of synapse assembly	IDA IDA: 通过直接分析推断	15797875	RGD
involved in positive regulation of synaptic transmission, GABAergic	IDA IDA: 通过直接分析推断	12930820	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IDA IDA: 通过直接分析推断	19730411	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: 通过突变表型推断	19628693	RGD
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: 通过突变表型推断	19628693	RGD
involved in positive regulation of synaptic vesicle exocytosis	IMP IMP: 通过突变表型推断	19628693	RGD
involved in postsynaptic density protein 95 clustering	IDA IDA: 通过直接分析推断	19450252	RGD
involved in postsynaptic density protein 95 clustering	IMP IMP: 通过突变表型推断	12930820	RGD
involved in presynaptic membrane assembly	IDA IDA: 通过直接分析推断	15797875	RGD
involved in protein targeting	IDA IDA: 通过直接分析推断	9278515	RGD
involved in regulation of AMPA receptor activity	IDA IDA: 通过直接分析推断	17582332	RGD
involved in regulation of NMDA receptor activity	IDA IDA: 通过直接分析推断	17582332	RGD
involved in regulation of NMDA receptor activity	IMP IMP: 通过突变表型推断	19628693	RGD
involved in regulation of presynapse organization	EXP EXP: 通过实验结果推断	10892652	RGD
involved in regulation of presynapse organization	IDA IDA: 通过直接分析推断	10892652	RGD
involved in regulation of presynapse organization	IMP IMP: 通过突变表型推断	10892652	RGD
involved in synapse assembly	IDA IDA: 通过直接分析推断	15797875	RGD
acts upstream of or within synapse organization	IDA IDA: 通过直接分析推断	15681343	RGD
involved in synaptic vesicle clustering	IDA IDA: 通过直接分析推断	20534458	RGD
involved in synaptic vesicle clustering	IMP IMP: 通过突变表型推断	19628693	RGD
involved in synaptic vesicle transport	IMP IMP: 通过突变表型推断	19628693	RGD
involved in terminal button organization	IMP IMP: 通过突变表型推断	19628693	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	15519238	RGD
located in cell surface	IDA IDA: 通过直接分析推断	15797875	RGD
located in dendrite	IDA IDA: 通过直接分析推断	17582332	RGD
located in dendritic shaft	IDA IDA: 通过直接分析推断	22539981	RGD
located in dendritic spine	IDA IDA: 通过直接分析推断	15519238	RGD
located in filopodium tip	IDA IDA: 通过直接分析推断	19450252	RGD
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	9927700	RGD
located in plasma membrane	IDA IDA: 通过直接分析推断	15519238	RGD
is active in postsynaptic specialization membrane	IDA IDA: 通过直接分析推断	9927700	RGD
located in postsynaptic specialization membrane	IDA IDA: 通过直接分析推断	15519238	RGD
located in synapse	IDA IDA: 通过直接分析推断	9278515	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

neuroligin-1

neuroligin I

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09339	NLGN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS19024	Nlgn1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS25513	Nlgn1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Nlgn1	NCBI	NCBI:22871
Mus musculus	Nlgn1	NCBI	NCBI:192167

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Nlgn1 - neuroligin 1 Gene

关于 Nlgn1

功能概要

Nlgn1 基因产物(1)

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Nlgn1 - neuroligin 1 Gene

关于 Nlgn1

功能概要

Nlgn1 基因产物(1)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z