2. Gene
  3. Aspm - abnormal spindle microtubule assembly Gene

Aspm - abnormal spindle microtubule assembly Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Sha1; MCPH5; Calmbp1; D330028K02Rik

基因 ID: 12316 | 基因类型: protein coding

关于 Aspm

功能概要

Enables Calmodulin binding activity. Involved in regulation of meiotic cell cycle. Acts upstream of or within several processes, including gamete generation; maintenance of centrosome location; and nervous system development. Located in cytoplasm; microtubule cytoskeleton; and midbody. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; nervous system; and perichondrium. Used to study microcephaly. Human ortholog(s) of this gene implicated in microcephaly; primary autosomal recessive microcephaly; primary autosomal recessive microcephaly 5; and visual epilepsy. Orthologous to human ASPM (assembly factor for spindle microtubules). [provided by Alliance of Genome Resources, Apr 2022]

Aspm 基因产物(1)

mRNA Protein Name
NM_009791.4 NP_033921.3 abnormal spindle-like microcephaly-associated protein homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calmodulin binding IDA
IDA: 通过直接分析推断
23152892 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of asymmetric cell division IMP
IMP: 通过突变表型推断
16798874 MGI
acts upstream of or within brain development IMP
IMP: 通过突变表型推断
20823249 MGI
acts upstream of or within cerebral cortex development IMP
IMP: 通过突变表型推断
24220505 MGI
acts upstream of or within developmental growth IMP
IMP: 通过突变表型推断
20823249 MGI
acts upstream of or within forebrain neuroblast division IMP
IMP: 通过突变表型推断
16798874 MGI
acts upstream of or within maintenance of centrosome location IMP
IMP: 通过突变表型推断
16798874 MGI
acts upstream of or within male gonad development IMP
IMP: 通过突变表型推断
24220505 MGI
acts upstream of or within meiotic spindle assembly IMP
IMP: 通过突变表型推断
23152892 MGI
acts upstream of or within negative regulation of asymmetric cell division IMP
IMP: 通过突变表型推断
16798874 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: 通过突变表型推断
16798874 MGI
acts upstream of neuroblast proliferation IGI
IGI: 通过遗传相互作用推断
21937711 MGI
acts upstream of neuroblast proliferation IMP
IMP: 通过突变表型推断
21937711 MGI
acts upstream of or within neuron migration IGI
IGI: 通过遗传相互作用推断
21937711 MGI
acts upstream of or within neuron migration IMP
IMP: 通过突变表型推断
21937711 MGI
acts upstream of or within neuronal stem cell population maintenance IMP
IMP: 通过突变表型推断
19896444 MGI
acts upstream of or within oogenesis IMP
IMP: 通过突变表型推断
20823249 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
21937711 MGI
acts upstream of or within positive regulation of neuroblast proliferation IGI
IGI: 通过遗传相互作用推断
21937711 MGI
acts upstream of or within positive regulation of neuroblast proliferation IMP
IMP: 通过突变表型推断
21937711 MGI
involved in regulation of meiotic cell cycle IMP
IMP: 通过突变表型推断
23152892 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
20823249 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23152892 MGI
located in meiotic spindle IDA
IDA: 通过直接分析推断
23152892 MGI
located in microtubule IDA
IDA: 通过直接分析推断
23152892 MGI
located in midbody IDA
IDA: 通过直接分析推断
20823249 MGI
located in mitotic spindle pole IDA
IDA: 通过直接分析推断
22031545 MGI
located in spindle pole IDA
IDA: 通过直接分析推断
16798874 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

abnormal spindle-like microcephaly-associated protein homolog

asp (abnormal spindle)-like, microcephaly associated

calmodulin-binding protein 1

calmodulin-binding protein Sha1

spindle and hydroxyurea checkpoint abnormal protein

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01104 ASPM Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21296 Aspm Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27815 Aspm Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Aspm NCBI NCBI:259266
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