2. Gene
  3. Lrp2 - low density lipoprotein receptor-related protein 2 Gene

Lrp2 - low density lipoprotein receptor-related protein 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Gp330; Megalin; b2b1625.2Clo; D230004K18Rik

基因 ID: 14725 | 基因类型: protein coding

关于 Lrp2

功能概要

Predicted to enable several functions, including PDZ domain binding activity; chaperone binding activity; and insulin-like growth factor I binding activity. Involved in several processes, including circulatory system development; nervous system development; and reproductive structure development. Acts upstream of or within several processes, including animal organ development; circulatory system development; and vitamin metabolic process. Located in several cellular components, including brush border membrane; clathrin-coated pit; and cytoplasmic vesicle. Is expressed in several structures, including egg cylinder; heart and pericardium; metanephros; ureter; and ventricular layer. Used to study Donnai-Barrow syndrome; Fanconi syndrome; and degenerative myopia. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrp2 基因产物(1)

mRNA Protein Name
NM_001081088.2 NP_001074557.1 low-density lipoprotein receptor-related protein 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10772929 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within aorta development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within cell population proliferation IMP
IMP: 通过突变表型推断
15623804 MGI
involved in coronary artery morphogenesis IMP
IMP: 通过突变表型推断
26822476 MGI
acts upstream of or within coronary vasculature development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within cranial skeletal system development IMP
IMP: 通过突变表型推断
34463328 MGI
acts upstream of or within diol metabolic process IMP
IMP: 通过突变表型推断
10052453 MGI
involved in folate import across plasma membrane IMP
IMP: 通过突变表型推断
24639464 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
15623804 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
34463328 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
27002738 MGI
involved in male gonad development IMP
IMP: 通过突变表型推断
16143106 MGI
involved in negative regulation of BMP signaling pathway IMP
IMP: 通过突变表型推断
20460439 MGI
involved in neural tube closure IMP
IMP: 通过突变表型推断
24639464 MGI
involved in neuron projection arborization IMP
IMP: 通过突变表型推断
20637285 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: 通过突变表型推断
34463328 MGI
involved in outflow tract septum morphogenesis IMP
IMP: 通过突变表型推断
26822476 MGI
involved in positive regulation of neurogenesis IMP
IMP: 通过突变表型推断
20460439 MGI
involved in positive regulation of oligodendrocyte progenitor proliferation IMP
IMP: 通过突变表型推断
22354480 MGI
involved in protein transport IDA
IDA: 通过直接分析推断
17324488 MGI
involved in pulmonary artery morphogenesis IMP
IMP: 通过突变表型推断
26822476 MGI
involved in receptor-mediated endocytosis IDA
IDA: 通过直接分析推断
15623804 MGI
acts upstream of or within receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
10052453 MGI
involved in receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
12724130 MGI
involved in response to leptin IDA
IDA: 通过直接分析推断
17324488 MGI
involved in secondary heart field specification IMP
IMP: 通过突变表型推断
26822476 MGI
involved in sensory perception of sound IMP
IMP: 通过突变表型推断
17846082 MGI
involved in vagina development IMP
IMP: 通过突变表型推断
16143106 MGI
involved in ventricular compact myocardium morphogenesis IMP
IMP: 通过突变表型推断
26822476 MGI
acts upstream of or within ventricular septum development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within vitamin D metabolic process IMP
IMP: 通过突变表型推断
10052453 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
15616221 MGI
located in apical part of cell IDA
IDA: 通过直接分析推断
15342463 MGI
located in apical plasma membrane IDA
IDA: 通过直接分析推断
15616221 MGI
located in axon IDA
IDA: 通过直接分析推断
20637285 MGI
located in brush border IDA
IDA: 通过直接分析推断
12815097 MGI
located in brush border membrane IDA
IDA: 通过直接分析推断
10662735 MGI
located in clathrin-coated pit IDA
IDA: 通过直接分析推断
15616221 MGI
located in dendrite IDA
IDA: 通过直接分析推断
20637285 MGI
located in endocytic vesicle IDA
IDA: 通过直接分析推断
15616221 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
15616221 MGI
located in endosome IDA
IDA: 通过直接分析推断
10766831 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
16143106 MGI
located in membrane IDA
IDA: 通过直接分析推断
15082773 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
16901941 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

low-density lipoprotein receptor-related protein 2

glycoprotein 330

Lrp2 抗体

目录号 产品名 应用 反应物种
HY-P86698 LRP2 Antibody (YA6390) IHC-P, WB, IF-Tissue, IHC-F, ICC/IF Mouse, Rat, Human

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07797 LRP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17962 Lrp2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24433 Lrp2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lrp2 NCBI NCBI:4036
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z