DEFA4 - defensin alpha 4 Gene

中文名称：防御素α4

种属: Homo sapiens

同用名: HP4; DEF4; HP-4; HNP-4

关于 DEFA4

功能概要

防御素是一类被认为参与宿主防御的抗菌和细胞毒性肽。它们大量存在于中性粒细胞颗粒中，也存在于粘膜表面的上皮细胞中，例如肠道、呼吸道、泌尿道和阴道。防御素家族的成员在蛋白质序列上高度相似，并以保守的半胱氨酸基序为特征。几个 alpha 防御素基因聚集在 8 号染色体上。这个基因与这个家族的其他基因的不同之处在于一个额外的 83 个碱基片段，这显然是编码区最近复制的结果。由该基因编码的蛋白质防御素 alpha 4 存在于嗜中性粒细胞中；它表现出皮质激素活性并抑制促肾上腺皮质激素刺激的皮质酮产生。[RefSeq 提供，2014 年 10 月]

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from Other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014]