2. Gene
  3. Ptbp1 - polypyrimidine tract binding protein 1 Gene

Ptbp1 - polypyrimidine tract binding protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ptb; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1

基因 ID: 19205 | 基因类型: protein coding

关于 Ptbp1

功能概要

Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome and negative regulation of neuron differentiation. Acts upstream of with a negative effect on gene expression. Acts upstream of or within neurogenesis and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and sensory organ. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptbp1 基因产物(8)

mRNA Protein Name
NM_001077363.3 NP_001070831.1 polypyrimidine tract-binding protein 1 isoform 1
NM_001283013.2 NP_001269942.1 polypyrimidine tract-binding protein 1 isoform 3
NM_001407385.1 NP_001394314.1 polypyrimidine tract-binding protein 1 isoform 4
NM_001407387.1 NP_001394316.1 polypyrimidine tract-binding protein 1 isoform 4
NM_001407389.1 NP_001394318.1 polypyrimidine tract-binding protein 1 isoform 5
NM_001407391.1 NP_001394320.1 polypyrimidine tract-binding protein 1 isoform 6
NM_001407393.1 NP_001394322.1 polypyrimidine tract-binding protein 1 isoform 6
NM_008956.4 NP_032982.2 polypyrimidine tract-binding protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IPI
IPI: 通过物理相互作用推断
25800779 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16051233 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of negative effect gene expression IGI
IGI: 通过遗传相互作用推断
25800779 MGI
acts upstream of negative effect gene expression IMP
IMP: 通过突变表型推断
25800779 MGI
involved in negative regulation of mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
17679093 MGI
acts upstream of or within negative regulation of mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
23636947 MGI
involved in negative regulation of neuron differentiation IDA
IDA: 通过直接分析推断
17679093 MGI
acts upstream of or within neurogenesis IMP
IMP: 通过突变表型推断
25800779 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
24530304 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
10716735 MGI
is active in nucleus IPI
IPI: 通过物理相互作用推断
25800779 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

polypyrimidine tract-binding protein 1

heterogeneous nuclear ribonucleoprotein I

hnRNP I

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P5960 PTBP1-RNA-binding inhibitor P6 TFA 99.49% 否
HY-P5959 PTBP1 α3-helix derived peptide P1 TFA Inhibitor 98.88% 否
HY-167832 PT109 Inhibitor 99.20% 否
HY-RS11351 PTBP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17773 Ptbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24240 Ptbp1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptbp1 NCBI NCBI:5725
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