2. Gene
  3. Edem1 - ER degradation enhancer, mannosidase alpha-like 1 Gene

Edem1 - ER degradation enhancer, mannosidase alpha-like 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: EDEM; mKIAA0212; A130059K23Rik

基因 ID: 192193 | 基因类型: protein coding

关于 Edem1

功能概要

Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in positive regulation of retrograde protein transport, ER to cytosol and trimming of terminal mannose on C branch. Acts upstream of or within ubiquitin-dependent ERAD pathway. Is integral component of endoplasmic reticulum membrane. Is expressed in embryo and liver. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Edem1 基因产物(1)

mRNA Protein Name
NM_138677.2 NP_619618.1 ER degradation-enhancing alpha-mannosidase-like protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables alpha-mannosidase activity IDA
IDA: 通过直接分析推断
11375934 MGI
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
IMP: 通过突变表型推断
20065073 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
21329881 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within ERAD pathway IDA
IDA: 通过直接分析推断
11375934 MGI
involved in positive regulation of retrograde protein transport, ER to cytosol IDA
IDA: 通过直接分析推断
24200403 MGI
involved in trimming of terminal mannose on C branch IMP
IMP: 通过突变表型推断
20065073 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
11375934 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ER degradation-enhancing alpha-mannosidase-like protein 1

ER degradation ER degradation enhancer, mannosidase alpha-like 1

ER degradation-enhancing alpha-mannosidase-like 1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-131986 LASSBio-1135 Antagonist 99.05% 否
HY-RS04157 EDEM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS22478 Edem1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS29001 Edem1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Edem1 NCBI NCBI:9695
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