2. Gene
  3. Ptgs2 - prostaglandin-endoperoxide synthase 2 Gene

Ptgs2 - prostaglandin-endoperoxide synthase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: COX2; Cox-2; PES-2; PHS-2; Pghs2; TIS10; PGHS-2; PHS II; gripghs

基因 ID: 19225 | 基因类型: protein coding

关于 Ptgs2

功能概要

This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with Cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs. [provided by RefSeq, Sep 2015]

Ptgs2 基因产物(1)

mRNA Protein Name
NM_011198.5 NP_035328.2 prostaglandin G/H synthase 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heme binding IDA
IDA: 通过直接分析推断
12925531 MGI
enables prostaglandin-endoperoxide synthase activity IDA
IDA: 通过直接分析推断
1419907 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18650379 MGI
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
12925531 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within anagen IMP
IMP: 通过突变表型推断
15713628 MGI
involved in brown fat cell differentiation IMP
IMP: 通过突变表型推断
20448152 MGI
acts upstream of or within cellular response to fluid shear stress IDA
IDA: 通过直接分析推断
24841674 MGI
involved in cellular response to non-ionic osmotic stress IMP
IMP: 通过突变表型推断
21716255 MGI
acts upstream of or within cyclooxygenase pathway IDA
IDA: 通过直接分析推断
1419907 MGI
involved in cyclooxygenase pathway IDA
IDA: 通过直接分析推断
12925531 MGI
acts upstream of or within decidualization IMP
IMP: 通过突变表型推断
10385625 MGI
acts upstream of or within embryo implantation IMP
IMP: 通过突变表型推断
10385625 MGI
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
21716255 MGI
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
21716255 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IMP
IMP: 通过突变表型推断
21716255 MGI
involved in positive regulation of brown fat cell differentiation IMP
IMP: 通过突变表型推断
20448152 MGI
involved in positive regulation of fever generation IDA
IDA: 通过直接分析推断
19940926 MGI
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
21716255 MGI
involved in positive regulation of prostaglandin biosynthetic process IMP
IMP: 通过突变表型推断
21716255 MGI
involved in prostaglandin biosynthetic process IDA
IDA: 通过直接分析推断
12925531 MGI
acts upstream of or within prostaglandin secretion IMP
IMP: 通过突变表型推断
32484881 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: 通过突变表型推断
12093889 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
8945508 MGI
involved in regulation of neuroinflammatory response IDA
IDA: 通过直接分析推断
29662056 MGI
acts upstream of or within response to nematode IDA
IDA: 通过直接分析推断
26644468 MGI
acts upstream of or within response to nematode IMP
IMP: 通过突变表型推断
32484881 MGI
acts upstream of or within response to selenium ion IDA
IDA: 通过直接分析推断
26644468 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12021206 MGI
located in cytoplasm IMP
IMP: 通过突变表型推断
21716255 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
12355421 MGI
located in nuclear inner membrane IDA
IDA: 通过直接分析推断
9545330 MGI
located in nuclear outer membrane IDA
IDA: 通过直接分析推断
9545330 MGI
NOT located in nucleus IDA
IDA: 通过直接分析推断
12021206 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

prostaglandin G/H synthase 2

PGH synthase 2

cyclooxygenase-2

glucocorticoid-regulated inflammatory cyclooxygenase

macrophage activation-associated marker protein P71/73

prostaglandin H2 synthase 2

Ptgs2 抗体

目录号 产品名 应用 反应物种
HY-P82796 Cyclooxygenase 2 Antibody (YA2541) WB, ICC/IF, IP Mouse

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N6929 Angelic acid 99.20% 否
HY-121025 BUR1 Inhibitor 99.65% 否
HY-RS11393 PTGS2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16902 Ptgs2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23344 Ptgs2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptgs2 NCBI NCBI:5743
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