Itgb4 - integrin beta 4 Gene

种属: Mus musculus

同用名: CD104; C230078O20

关于 Itgb4

功能概要

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated Transmembrane Glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the Integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]