2. Gene
  3. Tcf3 - transcription factor 3 Gene

Tcf3 - transcription factor 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: A1; E12; E2A; E47; KA1; ME2; ALF2; Pan1; Pan2; VDIR; TCF-3; Tcfe2a; E12/E47; bHLHb21

基因 ID: 21423 | 基因类型: protein coding

关于 Tcf3

功能概要

Enables several functions, including E-box binding activity; protein heterodimerization activity; and transmembrane receptor protein tyrosine kinase activator activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in gastrulation; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including histone acetylation; immune system development; and regulation of gene expression. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex and nucleosome. Is expressed in several structures, including branchial arch; central nervous system; male reproductive system; retina; and urinary system. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal Cancer. Orthologous to human TCF3 (transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tcf3 基因产物(16)

mRNA Protein Name
NM_001164147.2 NP_001157619.1 transcription factor E2-alpha isoform 1
NM_001164148.2 NP_001157620.1 transcription factor E2-alpha isoform 2
NM_001164149.2 NP_001157621.1 transcription factor E2-alpha isoform 3
NM_001164150.2 NP_001157622.1 transcription factor E2-alpha isoform 4
NM_001164151.2 NP_001157623.1 transcription factor E2-alpha isoform 5
NM_001164152.2 NP_001157624.1 transcription factor E2-alpha isoform 6
NM_001164153.2 NP_001157625.1 transcription factor E2-alpha isoform 7
NM_001378903.1 NP_001365832.1 transcription factor E2-alpha isoform 9
NM_001378904.1 NP_001365833.1 transcription factor E2-alpha isoform 10
NM_001378905.1 NP_001365834.1 transcription factor E2-alpha isoform 11
NM_001378908.1 NP_001365837.1 transcription factor E2-alpha isoform 12
NM_001378910.1 NP_001365839.1 transcription factor E2-alpha isoform 13
NM_001378912.1 NP_001365841.1 transcription factor E2-alpha isoform 14
NM_001378913.1 NP_001365842.1 transcription factor E2-alpha isoform 15
NM_001378914.1 NP_001365843.1 transcription factor E2-alpha isoform 16
NM_011548.5 NP_035678.3 transcription factor E2-alpha isoform 8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
18361414 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11812799 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
12446773 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
16673016 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
12200424 MGI
contributes to E-box binding IDA
IDA: 通过直接分析推断
11812799 MGI
enables E-box binding IDA
IDA: 通过直接分析推断
15226298 MGI
enables E-box binding IPI
IPI: 通过物理相互作用推断
9545521 MGI
contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
18361414 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12446773 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
12446773 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
11812799 MGI
enables bHLH transcription factor binding IPI
IPI: 通过物理相互作用推断
9545521 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
18550854 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16140986 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
14757642 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10924525 MGI
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
18214987 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16428437 MGI
enables sequence-specific DNA binding IGI
IGI: 通过遗传相互作用推断
12070084 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Peyer's patch development IGI
IGI: 通过遗传相互作用推断
17452521 MGI
acts upstream of or within T cell differentiation in thymus IMP
IMP: 通过突变表型推断
18958875 MGI
acts upstream of or within cell development IGI
IGI: 通过遗传相互作用推断
17452521 MGI
acts upstream of or within chromatin remodeling IMP
IMP: 通过突变表型推断
16428437 MGI
involved in gastrulation IGI
IGI: 通过遗传相互作用推断
21828274 MGI
acts upstream of gene expression IMP
IMP: 通过突变表型推断
18958875 MGI
acts upstream of or within immunoglobulin V(D)J recombination IMP
IMP: 通过突变表型推断
16428437 MGI
acts upstream of or within lymphocyte differentiation IMP
IMP: 通过突变表型推断
18958875 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: 通过遗传相互作用推断
17452521 MGI
acts upstream of or within positive regulation of DNA-templated transcription IGI
IGI: 通过遗传相互作用推断
12070084 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: 通过突变表型推断
18958875 MGI
involved in positive regulation of neuron differentiation IDA
IDA: 通过直接分析推断
18214987 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8760303 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11812799 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
8900141 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
12446773 MGI
acts upstream of or within protein stabilization IDA
IDA: 通过直接分析推断
15322112 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15351717 MGI
acts upstream of or within regulation of DNA-templated transcription IGI
IGI: 通过遗传相互作用推断
9676199 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19796622 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: 通过突变表型推断
16428437 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
16428437 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16428437 MGI
acts upstream of positive effect transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16673016 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
18361414 MGI
part of RNA polymerase II transcription regulator complex IMP
IMP: 通过突变表型推断
30426815 MGI
located in cytosol IDA
IDA: 通过直接分析推断
17507657 MGI
part of nucleosome IDA
IDA: 通过直接分析推断
16428437 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12200424 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
8760303 MGI
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
15314159 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcription factor E2-alpha

immunoglobulin enhancer-binding factor E12/E47

transcription factor A1

transcription factor E2a

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14306 TCF3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14309 TCF7L1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18501 Tcf3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24983 Tcf3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tcf3 NCBI NCBI:6929
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