ACSL1 - acyl-CoA synthetase long chain family member 1 Gene

中文名称：酰基辅酶 A 合成酶长链家族成员 1

种属: Homo sapiens

同用名: ACS1; LACS; FACL1; FACL2; LACS1; LACS2

基因 ID: 2180 | 基因类型: protein coding

关于 ACSL1

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:184,755,595-184,826,594 (from NCBI)

This gene has 16 transcripts (splice variants), 326 orthologues and 12 paralogues. Biased expression in fat (RPKM 357.3), liver (RPKM 217.4) and 10 other tissues.

功能概要

该基因编码的蛋白质是长链脂肪酸辅酶 A 连接酶家族的一种同工酶。尽管底物特异性、亚细胞定位和组织分布不同，但该家族的所有同工酶都将游离的长链脂肪酸转化为脂肪酰基辅酶 A 酯，从而在脂质生物合成和脂肪酸降解中发挥关键作用。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2013 年 11 月]

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A Ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

ACSL1 基因产物(18)

mRNA	Protein	Name
NM_001286708.2	NP_001273637.1	long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001286710.2	NP_001273639.1	long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001286711.2	NP_001273640.1	long-chain-fatty-acid--CoA ligase 1 isoform c
NM_001381877.1	NP_001368806.1	long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381878.1	NP_001368807.1	long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381879.1	NP_001368808.1	long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381880.1	NP_001368809.1	long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381881.1	NP_001368810.1	long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381882.1	NP_001368811.1	long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381883.1	NP_001368812.1	long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381884.1	NP_001368813.1	long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381885.1	NP_001368814.1	long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381886.1	NP_001368815.1	long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381887.1	NP_001368816.1	long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381888.1	NP_001368817.1	long-chain-fatty-acid--CoA ligase 1 isoform e
NM_001381889.1	NP_001368818.1	long-chain-fatty-acid--CoA ligase 1 isoform e
NM_001381890.1	NP_001368819.1	long-chain-fatty-acid--CoA ligase 1 isoform f
NM_001995.5	NP_001986.2	long-chain-fatty-acid--CoA ligase 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables long-chain fatty acid-CoA ligase activity	IDA IDA: 通过直接分析推断	21242590	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in fatty acid transport	IMP IMP: 通过突变表型推断	32521232	GOA
involved in lipid biosynthetic process	IDA IDA: 通过直接分析推断	21242590	GOA
involved in lipid biosynthetic process	IMP IMP: 通过突变表型推断	25592151	GOA
involved in long-chain fatty acid import into cell	IDA IDA: 通过直接分析推断	22022213	GOA
involved in long-chain fatty acid metabolic process	IDA IDA: 通过直接分析推断	22022213	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	24269233	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	22022213	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACSL1 蛋白结构

AMP-binding

0
200
400
600
698 a.a.

蛋白主名

其他名称

long-chain-fatty-acid--CoA ligase 1

LACS 1

关联疾病

疾病名称

别名

Retinal Dystrophy With Leukodystrophy

RDLKD	Acbd5 Deficiency
Dystrophy, Retinal, With Leukodystrophy

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00200	ACSL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS16255	Acsl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24003	Acsl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ACSL1	VGNC	VGNC:69564
Bos taurus	ACSL1	VGNC	VGNC:25564
Canis familiaris	ACSL1	VGNC	VGNC:37532
Felis catus	ACSL1	VGNC	VGNC:59534
Mus musculus	ACSL1	MGD	MGI:102797
Rattus norvegicus	ACSL1	RGD	RGD:2015
Others	ACSL1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ACSL1 - acyl-CoA synthetase long chain family member 1 Gene

关于 ACSL1

功能概要

ACSL1 基因产物(18)

ACSL1 蛋白结构

关联疾病

直系同源

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ACSL1 - acyl-CoA synthetase long chain family member 1 Gene

关于 ACSL1

功能概要

ACSL1 基因产物(18)

ACSL1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z