1. Gene
  2. Nrros - negative regulator of reactive oxygen species Gene

Nrros - negative regulator of reactive oxygen species Gene

种属: Mus musculus

同用名: Lrcc33; Lrrc33; E430025L02Rik

基因 ID: 224109 | 基因类型: protein coding

关于 Nrros

功能概要

Enables transforming growth factor beta binding activity. Involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Located in cell surface and endoplasmic reticulum. Is expressed in embryo and thymus primordium. Orthologous to human NRROS (negative regulator of Reactive Oxygen Species). [provided by Alliance of Genome Resources, Apr 2022]

Nrros 基因产物(3)

mRNA Protein Name
NM_001347181.1 NP_001334110.1 transforming growth factor beta activator LRRC33 isoform 2 precursor
NM_001347182.1 NP_001334111.1 transforming growth factor beta activator LRRC33 isoform 3
NM_146069.5 NP_666181.3 transforming growth factor beta activator LRRC33 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24739962 MGI
enables receptor ligand inhibitor activity IDA
IDA: 通过直接分析推断
29909984 MGI
enables transforming growth factor beta binding IPI
IPI: 通过物理相互作用推断
29909984 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in immune response IMP
IMP: 通过突变表型推断
24739962 MGI
involved in inflammatory response IMP
IMP: 通过突变表型推断
24739962 MGI
NOT involved in innate immune response IDA
IDA: 通过直接分析推断
29909984 MGI
involved in microglia development IMP
IMP: 通过突变表型推断
28459434 MGI
involved in sequestering of TGFbeta in extracellular matrix IDA
IDA: 通过直接分析推断
29909984 MGI
NOT involved in superoxide metabolic process IDA
IDA: 通过直接分析推断
29909984 MGI
involved in superoxide metabolic process IMP
IMP: 通过突变表型推断
24739962 MGI
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
29909984 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
29909984 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
24739962 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

transforming growth factor beta activator LRRC33

leucine rich repeat containing 33

leucine-rich repeat-containing protein 33

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nrros NCBI NCBI:375387