2. Gene
  3. Adrb2 - adrenoceptor beta 2 Gene

Adrb2 - adrenoceptor beta 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 24176 | 基因类型: protein coding

关于 Adrb2

功能概要

Enables several functions, including G-protein alpha-subunit binding activity; beta2-adrenergic receptor activity; and signaling receptor binding activity. Involved in several processes, including chemical synaptic transmission; positive regulation of ion transport; and response to steroid hormone. Located in several cellular components, including caveola; neuronal cell body membrane; and sarcolemma. Is active in glutamatergic synapse. Used to study cardiomyopathy (multiple); congestive heart failure; kidney disease (multiple); and lung disease (multiple). Biomarker of several diseases, including acute kidney failure; artery disease (multiple); congestive heart failure; polycystic ovary syndrome; and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Adrb2 基因产物(1)

mRNA Protein Name
NM_012492.2 NP_036624.2 beta-2 adrenergic receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables B2 bradykinin receptor binding IPI
IPI: 通过物理相互作用推断
20150590 RGD
enables G-protein alpha-subunit binding IPI
IPI: 通过物理相互作用推断
19942860 RGD
enables beta2-adrenergic receptor activity IDA
IDA: 通过直接分析推断
6247002 RGD
enables ionotropic glutamate receptor binding IPI
IPI: 通过物理相互作用推断
19942860 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
11441182 RGD
enables protein phosphatase 2A binding IPI
IPI: 通过物理相互作用推断
20395454 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
15141163 RGD
enables receptor-receptor interaction IPI
IPI: 通过物理相互作用推断
20395454 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
12514203 RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
2153813 RGD
involved in associative learning IDA
IDA: 通过直接分析推断
2573754 RGD
involved in cellular response to hypoxia IDA
IDA: 通过直接分析推断
19098126 RGD
involved in diaphragm contraction IDA
IDA: 通过直接分析推断
17362795 RGD
involved in estrous cycle IEP
IEP: 通过表达模式推断
7977723 RGD
involved in excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
17175110 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
7977723 RGD
involved in liver development IEP
IEP: 通过表达模式推断
8408243 RGD
involved in liver regeneration IEP
IEP: 通过表达模式推断
8855951 RGD
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
22495178 RGD
involved in negative regulation of ossification IMP
IMP: 通过突变表型推断
16177600 RGD
involved in negative regulation of urine volume IMP
IMP: 通过突变表型推断
7912752 RGD
involved in positive regulation of ATP-dependent activity IMP
IMP: 通过突变表型推断
8760245 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
15591297 RGD
involved in positive regulation of calcium ion import across plasma membrane IDA
IDA: 通过直接分析推断
11408541 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
16005083 RGD
involved in positive regulation of potassium ion transport IDA
IDA: 通过直接分析推断
6247002 RGD
involved in positive regulation of skeletal muscle tissue growth IMP
IMP: 通过突变表型推断
16177600 RGD
involved in positive regulation of sodium ion transport IDA
IDA: 通过直接分析推断
6247002 RGD
involved in positive regulation of the force of heart contraction by epinephrine IDA
IDA: 通过直接分析推断
19133992 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
17175110 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
17175110 RGD
involved in regulation of calcium ion transport IDA
IDA: 通过直接分析推断
12514203 RGD
involved in response to catecholamine IDA
IDA: 通过直接分析推断
6381693 RGD
involved in response to dexamethasone IEP
IEP: 通过表达模式推断
7588441 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
11431147 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
21562317 RGD
involved in response to monoamine IEP
IEP: 通过表达模式推断
1664493 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
1314813 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
2845194 RGD
involved in synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
17175110 RGD
involved in vasodilation IDA
IDA: 通过直接分析推断
15351777 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
11441182 RGD
located in axon IDA
IDA: 通过直接分析推断
15682824 RGD
located in caveola IDA
IDA: 通过直接分析推断
15961389 RGD
located in dendrite IDA
IDA: 通过直接分析推断
15682824 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
11441182 RGD
located in endosome IDA
IDA: 通过直接分析推断
12932836 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
17175110 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17175110 RGD
located in neuronal cell body membrane IDA
IDA: 通过直接分析推断
11441182 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
11441182 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
15961389 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

beta-2 adrenergic receptor

Adrenergic beta 2- receptor surface

adrenergic receptor, beta 2

adrenergic, beta-2-, receptor, surface

adrenoceptor beta 2, surface

beta-2 adrenoceptor

beta-2 adrenoreceptor

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14299A Indacaterol maleate Agonist 99.82% 否
HY-14299 Indacaterol Agonist 99.98% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-14299D Indacaterol acetate Agonist / Phase 4
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13338 Mabuterol Agonist 99.96% 否
HY-RS00415 ADRB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-14299B (S)-Indacaterol / 否
HY-152051S Mabuterol-d9 hydrochloride Agonist / 否
HY-RS16956 Adrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23399 Adrb2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W755295 Mabuterol hydrochloride Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adrb2 NCBI NCBI:154
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