2. Gene
  3. Tsc2 - TSC complex subunit 2 Gene

Tsc2 - TSC complex subunit 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Rc

基因 ID: 24855 | 基因类型: protein coding

关于 Tsc2

功能概要

Enables GTPase activator activity and protein N-terminus binding activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of signal transduction; and regulation of neuron projection development. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in several cellular components, including caveola; growth cone; and neuronal cell body. Part of protein-containing complex. Is active in glutamatergic synapse. Used to study autism spectrum disorder; hepatic angiomyolipoma; and renal cell carcinoma. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Tsc2 基因产物(1)

mRNA Protein Name
NM_012680.3 NP_036812.2 tuberin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
12869586 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9045618 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
15093748 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell projection organization IGI
IGI: 通过遗传相互作用推断
16286931 RGD
acts upstream of or within cell projection organization IMP
IMP: 通过突变表型推断
16286931 RGD
involved in establishment of cell polarity IMP
IMP: 通过突变表型推断
20530489 RGD
involved in negative regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
14612383 RGD
involved in negative regulation of TOR signaling IDA
IDA: 通过直接分析推断
12869586 RGD
involved in negative regulation of Wnt signaling pathway IDA
IDA: 通过直接分析推断
12511557 RGD
involved in negative regulation of axonogenesis IMP
IMP: 通过突变表型推断
18794346 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17376623 RGD
acts upstream of or within negative regulation of cell size IMP
IMP: 通过突变表型推断
16286931 RGD
involved in negative regulation of epithelial cell proliferation IDA
IDA: 通过直接分析推断
14612383 RGD
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
20813961 RGD
involved in negative regulation of fibroblast proliferation IDA
IDA: 通过直接分析推断
18056446 RGD
involved in negative regulation of macroautophagy IMP
IMP: 通过突变表型推断
24599401 RGD
involved in negative regulation of pinocytosis IMP
IMP: 通过突变表型推断
9045618 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
18056446 RGD
involved in negative regulation of vascular endothelial cell proliferation IMP
IMP: 通过突变表型推断
11553313 RGD
involved in positive regulation of cell adhesion IMP
IMP: 通过突变表型推断
20813961 RGD
involved in positive regulation of dendritic spine development IMP
IMP: 通过突变表型推断
16595860 RGD
involved in positive regulation of fibroblast migration IMP
IMP: 通过突变表型推断
20530489 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
17376623 RGD
involved in protein localization to cell surface IMP
IMP: 通过突变表型推断
20813961 RGD
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
24889507 RGD
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
24889507 RGD
involved in social behavior IMP
IMP: 通过突变表型推断
20927644 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in caveola IDA
IDA: 通过直接分析推断
15093748 RGD
located in cell projection IDA
IDA: 通过直接分析推断
17376623 RGD
located in dendrite IDA
IDA: 通过直接分析推断
15525761 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
24889507 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
24889507 RGD
located in growth cone IDA
IDA: 通过直接分析推断
14559897 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15525761 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
14559897 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tuberin

renal carcinoma

tuberous sclerosis 2 homolog protein

tuberous sclerosis 2 protein homolog

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134904 RMC-6272 Inhibitor 95.54% 否
HY-150229 306-N16B 99.27% 否
HY-134922 NS1-IN-1 Inhibitor / 否
HY-RS15132 TSC2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-155475 mTORC1-IN-2 Inhibitor / 否
HY-RS17096 Tsc2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23540 Tsc2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tsc2 NCBI NCBI:7249
Mus musculus Tsc2 NCBI NCBI:22084
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