GAS1 - growth arrest specific 1 Gene

中文名称：生长停滞特异性 1

种属: Homo sapiens

基因 ID: 2619 | 基因类型: protein coding

关于 GAS1

Cytogenetic location: 9q21.33 Genomic coordinates (GRCh38): 9:86,944,362-86,947,506 (from NCBI)

This gene has 1 transcript (splice variant), 216 orthologues and is associated with 6 phenotypes.

功能概要

生长停滞特异性 1 在生长抑制中起作用。 GAS1 阻止进入 S 期并阻止正常细胞和转化细胞的循环。 Gas1 是推定的肿瘤抑制基因。[RefSeq 提供，2008 年 7 月]

Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]

GAS1 基因产物(1)

mRNA	Protein	Name
NM_002048.3	NP_002039.2	growth arrest-specific protein 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21357679	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to vascular endothelial growth factor stimulus	IEP IEP: 通过表达模式推断	15070677	GOA
involved in negative regulation of mitotic cell cycle	IDA IDA: 通过直接分析推断	8127893	GOA
acts upstream of or within negative regulation of mitotic cell cycle	IGI IGI: 通过遗传相互作用推断	11356029	GOA
involved in negative regulation of protein processing	IMP IMP: 通过突变表型推断	21357679	GOA
involved in regulation of ER to Golgi vesicle-mediated transport	IMP IMP: 通过突变表型推断	21357679	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	8127893	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GAS1 蛋白结构

GDNF

0
100
200
300
345 a.a.

蛋白主名

其他名称

growth arrest-specific protein 1

GAS-1

关联疾病

疾病名称

别名

Septopreoptic Holoprosencephaly

Septopreoptic Hpe

Midline Interhemispheric Variant Of Holoprosencephaly

Mih	Mih Type Hpe
Mihf	Mihv
Middle Interhemispheric Fusion Variant	Middle Interhemispheric Variant Of Holoprosencephaly
Syntelencephaly

Microform Holoprosencephaly

Hpe, Minor Form	Hpe-L
Holoprosencephaly, Minor Form	Holoprosencephaly-Like
Microform Hpe

Lobar Holoprosencephaly

Alobar Holoprosencephaly

Semilobar Holoprosencephaly

Basal Cell Nevus Syndrome

Nevoid Basal Cell Carcinoma Syndrome	Gorlin Syndrome
Nbccs	BCNS
Gorlin-Goltz Syndrome	Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies
Cerebral Gigantism Jaw Cysts	Cramer Niederdellmann Syndrome
Gorlin Syndrome Or Gorlin-Goltz Syndrome	Naevoid Basal Cell Carcinoma Syndrome

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Ciliary Dyskinesia, Primary, 33

Primary Ciliary Dyskinesia 33	CILD33
Ciliary Dyskinesia, Primary, 33, Without Situs Inversus	Primary Ciliary Dyskinesia 33 Without Situs Inversus

Retinitis Pigmentosa 27

RP27	Retinal Degeneration, Autosomal Recessive, Clumped Pigment Type
Retinal Degeneration Autosomal Recessive Clumped Pigment Type	RDCP
Clumped Pigmentary Retinal Degeneration	Retinitis Pigmentosa, Type 27

Glioma

Solitary Median Maxillary Central Incisor

SMMCI	Fused Incisors
Single Upper Central Incisor	Single Central Maxillary Incisor
Single Median Maxillary Central Incisor	Solitary Median Maxillary Central Incisor Syndrome
Incisors Fused	Incisors, Fused

Pallister-Hall Syndrome

PHS	Hypothalamic Hamartomas
Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly	Hypothalamic Hamartoblastoma Syndrome
Hamartoma Of The Hypothalamus	Pallister Hall Syndrome
Hall-Pallister Syndrome	Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly
Hamartoma, Hypothalamic

Brachydactyly, Type A1

Brachydactyly Type A1	BDA1
Farabee-Type Brachydactyly	Farabee Type Brachydactyly
Brachydactyly Farabee Type	Brachydactyly, Farabee Type
Brachydactyly A1	Brachydactyly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-107199	N-Butylthiophosphoric triamide	Inhibitor	99.76%	否
HY-RS05281	GAS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-W016613	Tri(ethylene glycol) monoethyl ether		/	否
HY-RS22178	Gas1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS28700	Gas1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	GAS1	VGNC	VGNC:29256
Mus musculus	GAS1	MGD	MGI:95655
Canis familiaris	GAS1	VGNC	VGNC:41114
Rattus norvegicus	GAS1	RGD	RGD:1586820

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GAS1 - growth arrest specific 1 Gene

关于 GAS1

功能概要

GAS1 基因产物(1)

GAS1 蛋白结构

关联疾病

直系同源

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GAS1 - growth arrest specific 1 Gene

关于 GAS1

功能概要

GAS1 基因产物(1)

GAS1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z