1. Gene
  2. GBP2 - guanylate binding protein 2 Gene

GBP2 - guanylate binding protein 2 Gene

中文名称:鸟苷酸结合蛋白 2

种属: Homo sapiens

基因 ID: 2634 | 基因类型: protein coding

关于 GBP2

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,106,132-89,126,114 (from NCBI)

This gene has 4 transcripts (splice variants), 144 orthologues and 10 paralogues. Ubiquitous expression in appendix (RPKM 36.9), urinary bladder (RPKM 31.7) and 24 other tissues.

功能概要

该基因属于鸟嘌呤结合蛋白 (GBP) 家族,其中包括可与鸟嘌呤核苷酸 (GMP、GDP 和 GTP) 结合的干扰素诱导蛋白。编码的蛋白质是一种 GTP 酶,可水解 GTP,主要是生成 GDP。该蛋白可能作为鳞状细胞癌的标志物发挥作用。[RefSeq 提供,2013 年 7 月]

This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]

GBP2 基因产物(1)

mRNA Protein Name
NM_004120.5 NP_004111.2 guanylate-binding protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase inhibitor activity IDA
IDA: 通过直接分析推断
31091448 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21151871 GOA
enables molecular function inhibitor activity IDA
IDA: 通过直接分析推断
31091448 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18985028 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
21151871 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
17266443 GOA
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
17266443 GOA
involved in cellular response to type II interferon IDA
IDA: 通过直接分析推断
17266443 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
31091448 GOA
involved in protein localization to nucleus IDA
IDA: 通过直接分析推断
21151871 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Golgi apparatus IDA
IDA: 通过直接分析推断
31091448 GOA
located in Golgi apparatus IDA
IDA: 通过直接分析推断
17266443 GOA
is active in Golgi membrane IDA
IDA: 通过直接分析推断
31091448 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
21151871 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17266443 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
17266443 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GBP2 蛋白结构

GBP

GBP: Guanylate-binding protein, N-terminal domain (19 - 280)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (282 - 578)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 591 a.a.
蛋白主名 其他名称

guanylate-binding protein 2

GTP-binding protein 2

GBP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GBP2 P32456 GBP4 Homo sapiens Q96PP9 21151871
种属内
GBP2 P32456 GBP4 Homo sapiens Q96PP9 21151871
种属内
GBP2 P32456 GBP3 Homo sapiens Q9H0R5 28514442
种属内
GBP2 P32456 GBP3 Homo sapiens Q9H0R5 21151871
种属内
GBP2 P32456 GBP3 Homo sapiens Q9H0R5 21151871
种属内
GBP2 P32456 GBP3 Homo sapiens Q9H0R5 33961781
种属内
GBP2 P32456 GBP1 Homo sapiens P32455 21151871
种属内
GBP2 P32456 GBP1 Homo sapiens P32455 21151871
种属内
GBP2 P32456 GBP7 Homo sapiens Q8N8V2 33961781
种属内
GBP2 P32456 GBP2 Homo sapiens P32456
Y2H
21151871
种属内
GBP2 P32456 GBP2 Homo sapiens P32456 21151871
种属内
GBP2 P32456 GBP7 Homo sapiens Q8N8V2 28514442
种属内
GBP2 P32456 GBP2 Homo sapiens P32456 21151871
种属内
GBP2 P32456 HSP90AA5P Homo sapiens Q58FG0 33961781
种属内
GBP2 P32456 HSP90AA5P Homo sapiens Q58FG0 28514442
种属内
GBP2 P32456 GBP5 Homo sapiens Q96PP8 21151871
种属内
GBP2 P32456 GBP5 Homo sapiens Q96PP8 21151871
种属间
GBP2 P32456 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548 18985028
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GBP2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75787 GBP2 Protein, Human (HEK293, His) AAH73163.1 (M1-C588) ≥95%

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GBP2 RGD RGD:621810
Mus musculus GBP2 NCBI NCBI:14469
Others GBP2 NCBI