2. Gene
  3. EPHB2 - Ephb2 Eph receptor B2 Gene

EPHB2 - Ephb2 Eph receptor B2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: RGD1564232

基因 ID: 313633 | 基因类型: protein coding

关于 EPHB2

功能概要

Predicted to enable several functions, including amyloid-beta binding activity; identical protein binding activity; and transmembrane signaling receptor activity. Involved in several processes, including cell junction assembly; positive regulation of nervous system development; and regulation of gene expression. Located in Golgi apparatus; cell surface; and dendritic spine. Is active in glutamatergic synapse. Used to study irritable bowel syndrome and ulcerative colitis. Biomarker of irritable bowel syndrome and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EphB2 (EPH receptor B2). [provided by Alliance of Genome Resources, Apr 2022]

EPHB2 基因产物(1)

mRNA Protein Name
NM_001127319.3 NP_001120791.2 ephrin type-B receptor 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
21113149 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to amyloid-beta IEP
IEP: 通过表达模式推断
23831214 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
33794069 RGD
involved in hindbrain tangential cell migration IMP
IMP: 通过突变表型推断
28276447 RGD
involved in negative regulation of cytokine production involved in inflammatory response IDA
IDA: 通过直接分析推断
33722292 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
21364901 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
21113149 RGD
involved in positive regulation of protein localization to cell surface IDA
IDA: 通过直接分析推断
19160501 RGD
involved in positive regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
21113149 RGD
involved in positive regulation of synapse assembly IMP
IMP: 通过突变表型推断
21364901 RGD
involved in postsynaptic membrane assembly IDA
IDA: 通过直接分析推断
11136979 RGD
involved in postsynaptic membrane assembly IEP
IEP: 通过表达模式推断
11136979 RGD
involved in postsynaptic membrane assembly IMP
IMP: 通过突变表型推断
11136979 RGD
involved in regulation of T-helper 17 type immune response IDA
IDA: 通过直接分析推断
33722292 RGD
involved in regulation of behavioral fear response IMP
IMP: 通过突变表型推断
26354908 RGD
involved in regulation of filopodium assembly IMP
IMP: 通过突变表型推断
21364901 RGD
involved in regulation of receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
33722292 RGD
involved in tight junction assembly IDA
IDA: 通过直接分析推断
33722292 RGD
involved in vesicle-mediated intercellular transport IDA
IDA: 通过直接分析推断
33722292 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
15965473 RGD
located in dendrite IDA
IDA: 通过直接分析推断
15965473 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
16394100 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
11136979 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
11136979 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15965473 RGD
located in postsynapse IDA
IDA: 通过直接分析推断
19160501 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ephrin type-B receptor 2

ephrin type-B receptor 2-like

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18833 ALW-II-49-7 Inhibitor 99.77% 否
HY-P5438 Srctide Substrate 99.93% 否
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% 否
HY-157019 UniPR1447 Antagonist 99.46% 否
HY-146375 UniPR505 Antagonist / 否
HY-P10630 Pep63 Inhibitor / 否
HY-RS04434 EPHB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17199 Ephb2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23651 Ephb2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24537 Ephb1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990405 Anti-EphB2 Antibody Inhibitor 99.36% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens EPHB2 NCBI NCBI:2048
Macaca fascicularis EPHB2 NCBI NCBI:102137932
Mus musculus EPHB2 NCBI NCBI:13844
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