HOXC6 - homeobox C6 Gene

中文名称：同源框 C6

种属: Homo sapiens

同用名: CP25; HOX3; HOX3C; HHO.C8

关于 HOXC6

功能概要

该基因属于同源盒家族，其成员编码高度保守的转录因子家族，在所有多细胞生物的形态发生中起重要作用。哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，它们分别位于不同的染色体上，由 9～11 个串联排列的基因组成。该基因 HOXC6 是位于 12 号染色体簇中的几个 HOXC 基因之一。三个基因 HOXC5、HOXC4 和 HOXC6 共享一个 5' 非编码外显子。转录本可能包括与基因特异性外显子剪接的共享外显子，或者它们可能仅包括基因特异性外显子。已经为 HOXC6 鉴定了编码不同同种型的可变剪接转录物变体。转录变体二包括共享外显子，转录变体一仅包括基因特异性外显子。[RefSeq 提供，2008 年 7 月]

This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]