2. Gene
  3. ISG20 - interferon stimulated exonuclease gene 20 Gene

ISG20 - interferon stimulated exonuclease gene 20 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：干扰素刺激的核酸外切酶基因 20

种属: Homo sapiens

同用名: CD25; HEM45

基因 ID: 3669 | 基因类型: protein coding

关于 ISG20

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:88,635,632-88,656,483 (from NCBI)

This gene has 11 transcripts (splice variants), 197 orthologues and 5 paralogues. Biased expression in lymph node (RPKM 12.2), spleen (RPKM 8.7) and 13 other tissues.

功能概要

启用 3'-5' 核酸外切酶活性和 RNA 结合活性。参与对病毒的防御反应；病毒基因组复制的负调控；和含核碱基的化合物分解代谢过程。位于细胞质和核腔中。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3'-5' exonuclease activity and RNA binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Located in cytoplasm and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

ISG20 基因产物(6)

mRNA Protein Name
NM_001303233.2 NP_001290162.1 interferon-stimulated gene 20 kDa protein isoform a
NM_001303234.2 NP_001290163.1 interferon-stimulated gene 20 kDa protein isoform a
NM_001303235.2 NP_001290164.1 interferon-stimulated gene 20 kDa protein isoform b
NM_001303236.2 NP_001290165.1 interferon-stimulated gene 20 kDa protein isoform b
NM_001303237.2 NP_001290166.1 interferon-stimulated gene 20 kDa protein isoform c
NM_002201.6 NP_002192.2 interferon-stimulated gene 20 kDa protein isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5'-RNA exonuclease activity IDA
IDA: 通过直接分析推断
11401564 GOA
enables U1 snRNA binding IDA
IDA: 通过直接分析推断
16514659 GOA
enables U2 snRNA binding IDA
IDA: 通过直接分析推断
16514659 GOA
enables U3 snoRNA binding IDA
IDA: 通过直接分析推断
16514659 GOA
enables exonuclease activity IMP
IMP: 通过突变表型推断
21036379 GOA
enables single-stranded DNA 3'-5' DNA exonuclease activity IDA
IDA: 通过直接分析推断
11401564 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA catabolic process IDA
IDA: 通过直接分析推断
11401564 GOA
involved in RNA catabolic process IDA
IDA: 通过直接分析推断
11401564 GOA
involved in defense response to virus IMP
IMP: 通过突变表型推断
21036379 GOA
involved in negative regulation of viral genome replication IMP
IMP: 通过突变表型推断
21036379 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
12594219 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Cajal body IDA
IDA: 通过直接分析推断
16514659 GOA
located in PML body IDA
IDA: 通过直接分析推断
9235947 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
16514659 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
16514659 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21036379 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ISG20 蛋白结构

RNase_T

RNase_T: Exonuclease (8 - 162)

  • 0
  • 100
  • 181 a.a.
蛋白主名 其他名称

interferon-stimulated gene 20 kDa protein

estrogen-regulated transcript 45 protein

关联疾病

疾病名称 别名
Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos
Estrogen-Receptor Positive Breast Cancer
Subacute Delirium

Delirium

Acute Confusional State Nos
Yellow Fever

Urban Yellow Fever

Jungle Yellow Fever

Sylvatic Yellow Fever

Yf

Yellow Fever, Sylvan

Bronze John

Yellow Jack

Yf- [Yellow Fever]

Febris Flava
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections
Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125980 LX-3 Inhibitor 98.08% 否
HY-RS00424 AEN Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06930 ISG20 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS19856 Aen Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS20043 Isg20 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS26356 Aen Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS26546 Isg20 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ISG20 VGNC VGNC:67833
Bos taurus ISG20 VGNC VGNC:30294
Macaca mulatta ISG20 VGNC VGNC:73769
Canis familiaris ISG20 VGNC VGNC:42107
Mus musculus ISG20 MGD MGI:1928895
Rattus norvegicus ISG20 RGD RGD:1306407
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