2. Gene
  3. ITGA1 - integrin subunit alpha 1 Gene

ITGA1 - integrin subunit alpha 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：整合素亚基 alpha 1

种属: Homo sapiens

同用名: VLA1; CD49a

基因 ID: 3672 | 基因类型: protein coding

关于 ITGA1

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:52,787,916-52,959,209 (from NCBI)

This gene has 8 transcripts (splice variants), 232 orthologues and 17 paralogues. Broad expression in spleen (RPKM 48.2), placenta (RPKM 40.6) and 19 other tissues.

功能概要

该基因编码整合素受体的 alpha 1 亚基。这种蛋白质与 β1 亚基异二聚化形成胶原蛋白和层粘连蛋白的细胞表面受体。异二聚体受体参与细胞间粘附，并可能在炎症和纤维化中发挥作用。 α 1 亚基包含一个插入的 (I) von Willebrand 因子 I 型结构域，该结构域被认为与胶原蛋白结合有关。[RefSeq 提供，2008 年 7 月]

This gene encodes the alpha 1 subunit of Integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for Collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in Collagen binding. [provided by RefSeq, Jul 2008]

ITGA1 基因产物(1)

mRNA Protein Name
NM_181501.2 NP_852478.1 integrin alpha-1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables collagen binding involved in cell-matrix adhesion IMP
IMP: 通过突变表型推断
24823363 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16754661 GOA
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
15592458 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell-matrix adhesion IMP
IMP: 通过突变表型推断
24823363 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15592458 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19933311 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
11518510 GOA
part of integrin alpha1-beta1 complex IDA
IDA: 通过直接分析推断
24823363 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ITGA1 蛋白结构

VWA

VWA: von Willebrand factor type A domain (172 - 353)

FG-GAP

FG-GAP: FG-GAP repeat (571 - 606)

Integrin_alpha2

Integrin_alpha2: Integrin alpha (664 - 1041)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1179 a.a.
蛋白主名 其他名称

integrin alpha-1

CD49 antigen-like family member A

ITGA1 抗体

目录号 产品名 应用 反应物种
HY-P84411 ITGA1 Antibody (YA4108) IHC-P, ICC/IF, FC, ELISA Human

关联疾病

疾病名称 别名
Colon Carcinoma In Situ

Carcinoma In Situ Of Colon

Stage 0 Colonic Carcinoma

Stage 0 Carcinoma Of Colon

Intraepithelial Neoplasia Of Colon, High Grade

Carcinoma In Situ Of Cecum

Carcinoma In Situ Of Hepatic Flexure

Carcinoma In Situ Of Ileocecal Valve

Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia
Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia

Arvc

Arvd

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Arvc Cardiomyopathy

Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

Arvd/C

Right Ventricular Dysplasia, Arrhythmogenic

Ventricular Dysplasia, Right, Arrhythmogenic

Cardiomyopathy, Ventricular, Right, Arrhythmogenic

Dysplasia, Arrhythmogenic Right Ventricular
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06945 ITGA1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19449 Itga1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25941 Itga1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991434 SAN-300 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ITGA1 RGD RGD:2923
Mus musculus ITGA1 MGD MGI:96599
Macaca mulatta ITGA1 VGNC VGNC:73772
Felis catus ITGA1 VGNC VGNC:67836
Canis familiaris ITGA1 VGNC VGNC:42120
Bos taurus ITGA1 VGNC VGNC:30310
Others ITGA1 NCBI
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