1. Gene
  2. KCNG1 - potassium voltage-gated channel modifier subfamily G member 1 Gene

KCNG1 - potassium voltage-gated channel modifier subfamily G member 1 Gene

中文名称:钾电压门控通道调节因子亚科 G 成员 1

种属: Homo sapiens

同用名: K13; kH2; KCNG; KV6.1

基因 ID: 3755 | 基因类型: protein coding

关于 KCNG1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:51,003,656-51,023,107 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 31 paralogues. Biased expression in endometrium (RPKM 3.9), placenta (RPKM 2.0) and 11 other tissues.

功能概要

从功能和结构的角度来看,电压门控钾 (Kv) 通道代表了最复杂的一类电压门控离子通道。它们的不同功能包括调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质转运、平滑肌收缩和细胞体积。该基因编码钾通道、电压门控、G 亚科的成员。该基因在骨骼肌中大量表达。已在正常和癌变组织中发现多个选择性剪接的转录物变体。[RefSeq 提供,2008 年 7 月]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

KCNG1 基因产物(1)

mRNA Protein Name
NM_002237.4 NP_002228.2 potassium voltage-gated channel subfamily G member 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables potassium channel regulator activity IDA
IDA: 通过直接分析推断
19074135 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of voltage-gated potassium channel complex IDA
IDA: 通过直接分析推断
19074135 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KCNG1 蛋白结构

BTB_2

BTB_2: BTB/POZ domain (65 - 164)

Ion_trans

Ion_trans: Ion transport protein (270 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 513 a.a.
蛋白主名 其他名称

potassium voltage-gated channel subfamily G member 1

potassium channel KH2

关联疾病

疾病名称 别名
Coumarin Resistance

Warfarin Resistance

Warfarin Sensitivity

Coumadin Sensitivity

Warfarin Response

Poor Metabolism Of Coumarin

Coumarin, Poor Metabolism Of

CMRES

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus KCNG1 VGNC VGNC:30442
Mus musculus KCNG1 MGD MGI:3616086
Rattus norvegicus KCNG1 RGD RGD:631416
Macaca mulatta KCNG1 VGNC VGNC:73979
Canis familiaris KCNG1 VGNC VGNC:42245
Felis catus KCNG1 VGNC VGNC:67906