1. Gene
  2. KCNK3 - potassium two pore domain channel subfamily K member 3 Gene

KCNK3 - potassium two pore domain channel subfamily K member 3 Gene

中文名称:钾二孔域通道亚科 K 成员 3

种属: Homo sapiens

同用名: OAT1; PPH4; TASK; TASK1; TBAK1; K2p3.1; TASK-1

基因 ID: 3777 | 基因类型: protein coding

关于 KCNK3

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,692,722-26,733,420 (from NCBI)

This gene has 1 transcript (splice variant), 272 orthologues, 14 paralogues and is associated with 3 phenotypes. Biased expression in adrenal (RPKM 48.3), placenta (RPKM 12.8) and 5 other tissues.

功能概要

该基因编码含有两个成孔 P 结构域的钾通道蛋白超家族成员。编码的蛋白质是一种外向整流通道,对细胞外 pH 值的变化敏感,并受到细胞外酸化的抑制。也称为酸敏感钾通道,它被麻醉剂氟烷和异氟醚激活。虽然在 northern 印迹中检测到三个转录本,但目前没有序列可用于确认该基因的转录本变体。[RefSeq 提供,2008 年 8 月]

This gene encodes a member of the superfamily of Potassium Channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive Potassium Channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

KCNK3 基因产物(1)

mRNA Protein Name
NM_002246.3 NP_002237.1 potassium channel subfamily K member 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables S100 protein binding IPI
IPI: 通过物理相互作用推断
12198146 GOA
enables monoatomic ion channel activity IMP
IMP: 通过突变表型推断
12198146 GOA
enables outward rectifier potassium channel activity IDA
IDA: 通过直接分析推断
26919430 GOA
enables potassium ion leak channel activity IDA
IDA: 通过直接分析推断
9312005 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in monoatomic ion transmembrane transport IMP
IMP: 通过突变表型推断
12198146 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IMP
IMP: 通过突变表型推断
12198146 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KCNK3 蛋白结构

Ion_trans_2

Ion_trans_2: Ion channel (77 - 132)

Ion_trans_2

Ion_trans_2: Ion channel (166 - 247)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
蛋白主名 其他名称

potassium channel subfamily K member 3

TWIK-related acid-sensitive K(+) channel 1

关联疾病

疾病名称 别名
Pulmonary Hypertension, Primary, 4

PPH4

Hypertension, Pulmonary, Primary, Type 4

Heritable Pulmonary Arterial Hypertension

Fpah

Familial Pulmonary Arterial Hypertension

Hpah

Hereditary Pulmonary Arterial Hypertension

Familial Primary Pulmonary Hypertension

Pulmonary Hypertension, Primary, 1

Pulmonary Arterial Hypertension

Pah

Idiopathic Pulmonary Arterial Hypertension

Idiopathic Pulmonary Hypertension

Primary Pulmonary Hypertension

PPH1

Pulmonary Hypertension, Primary, Fenfluramine Or Dexfenfluramine-Associated

Pulmonary Hypertension, Familial Primary, 1, With Or Without Hht

Pph

Familial Primary Pulmonary Hypertension

Sporadic Primary Pulmonary Hypertension

Pht

Fpah

Familial Pulmonary Arterial Hypertension

Hereditary Pulmonary Arterial Hypertension

Heritable Pulmonary Arterial Hypertension

Ayerza Syndrome

Fpph

Ppht

Ipah

Primary Pulmonary Arterial Hypertension

Pulmonary Hypertension, Familial Primary

Hypertension, Pulmonary, Primary, Type 1

Ayerza'S Syndrome

Pah - [Pulmonary Arterial Hypertension]

Arrillaga Ayerza Syndrome

Pulmonary Hypertension

Primary Pulmonary Hypertension

Hypertension Pulmonary

Hypertension, Pulmonary

Hypertension, Pulmonary, Primary

Idiopathic Pulmonary Hypertension

Idiopathic Pulmonary Arterial Hypertension

Pulmonary Htn - [Hypertension]

Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome

BIBARS

Mental Retardation With Hypotonia And Facial Dysmorphism

Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome

Kcnk9 Imprinting Syndrome

Pulmonary Venoocclusive Disease

Pulmonary Veno-Occlusive Disease

Obstructive Disease Of The Pulmonary Veins

Pvod

Isolated Pulmonary Venous Sclerosis

Venous Form Of Primary Pulmonary Hypertension

Pulmonary Venoocclusive Disease 1, Autosomal Dominant

Ischiocoxopodopatellar Syndrome With Or Without Pulmonary Arterial Hypertension

Small Patella Syndrome

Ischiopatellar Dysplasia

Coxopodopatellar Syndrome

Scott-Taor Syndrome

Sps

Ischiocoxopodopatellar Syndrome

Patella Aplasia, Coxa Vara, And Tarsal Synostosis

ICPPS

Congenital Coxa Vara, Patella Aplasia And Tarsal Synostosis

Coxo-Podo-Patellar Syndrome

Patella Aplasia, Coxa Vara, Tarsal Synostosis

Coxopodipatellar Syndrome

Sleep Apnea

Sleep Apnea Syndromes

Central Sleep Apnea

Central Sleep Apnea Syndrome

Sleep Apnea, Central

Primary Central Sleep Apnea

Central Sleep Apnea, Primary

Central Sleep Apnoea Syndrome

Csa - [Central Sleep Apnoea]

Csas - [Central Sleep Apnoea Syndrome]

Central Sleep Apnoea Due To Substances Including Medications

Conn'S Syndrome

Cushing Syndrome

Hyperaldosteronism

Primary Hyperaldosteronism

Hypercortisolism

Primary Aldosteronism

Cushing'S Syndrome

Adrenal Gland Hyperfunction

Conn Syndrome

Hyperadrenalism

Ectopic Acth Syndrome

Hyperadrenocorticism

Cushing Disease

Cushing'S Disease

Adrenal Cortex Adenoma

Corticotroph Pituitary Adenoma

Pituitary Corticotroph Micro-Adenoma

Pituitary-Dependent Cushing Syndrome

Pituitary Acth Hypersecretion

Acth Syndrome, Ectopic

Acth-Secreting Pituitary Adenoma

Adrenal Hyperfunction Resulting From Pituitary Acth Excess

Ectopic Adrenocorticotropic Hormone Syndrome

Nodular Primary Adrenocortical Dysplasia

Pituitary Dependent Cushing Syndrome

Pituitary Cushing Syndrome

Pituitary-Dependant Cushing Syndrome

Pituitary-Dependant Hypercortisolism

Pituitary-Dependant Hypercortisolism Disorder

Aldosteronism Primary

Acth Syndrome Ectopic

Adrenal Cushing'S Syndrome

Adrenal Cortical Adenoma

Cushing Syndrome Nos

Cortisol Hypersecretion

Corticoadrenal Hypersecretion

Cushing Syndrome Secondary To Ectopic Acth-Secretion

Ectopic Cushing Syndrome

Hypercortisolism Due To Nonpituitary Tumour

Ectopic Acth - [Adrenocorticotropic Hormone] Secretion

Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome

Idiopathic Aldosteronism

Aldosteronism

Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia

Primary Aldosteronism Due To Adrenal Hyperplasia

Chronic Pulmonary Heart Disease
Pulmonary Valve Insufficiency

Pulmonary Regurgitation

Pulmonary Incompetence

Pulmonary Incompetence, Non-Rheumatic

Pulmonary Insufficiency Following Trauma And Surgery

Pulmonary Regurg.

Pulmonic Insufficiency

Pulmonic Valve Regurgitation

Pulmonary Valve Incompetence

Pulmonary Valve Incompetency

Pulmonary Valvular Insufficiency

Pulmonary Valvular Regurgitation

Pulmonary Valvular Incompetency

Pulmonary Valve Incompetence Nos

Annular Incompetency Pulmonary Valve

Incompetent Pulmonary Valve

Graham Steell Murmur

Pulmonary Valvular Incompetence

Cantu Syndrome

Hypertrichotic Osteochondrodysplasia

Hypertrichotic Osteochondrodysplasia Cantu Type

Cantú Syndrome

Craniofaciocardioskeletal Syndrome

Hypertrichosis-Osteochondrodysplasia-Cardiomegaly Syndrome

Congenital Hypertrichosis-Acromegaloid Facial Features Spectrum

Congenital Hypertrichosis-Coarse Facial Features Spectrum

HTOCD

Osteochondrodysplasia, Hypertrichotic

Congenital Central Hypoventilation Syndrome

Cchs

Haddad Syndrome

Ondine Curse

Ondine Syndrome

Congenital Central Hypoventilation

Congenital Central Alveolar Hypoventilation Syndrome

Congenital Failure Of Autonomic Control

Ondine'S Curse

Primary Alveolar Hypoventilation

Ondine-Hirschsprung Disease

Central Congenital Hypoventilation Syndrome

Congenital Ondine Curse

Idiopathic Congenital Central Alveolar Hypoventilation

Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome

Ondine-Hirschsprung Syndrome

Hereditary Hemorrhagic Telangiectasia

Rendu-Osler-Weber Disease

Hht

Osler-Weber-Rendu Disease

Telangiectasia, Hereditary Hemorrhagic

Osler Hemorrhagic Telangiectasia Syndrome

Orw Disease

Osler Weber Rendu Syndrome

Osler-Rendu-Weber Disease

Osler-Weber-Rendu Syndrome

Rendu-Osler Disease

Telangiectasia Hereditary Hemorrhagic

Telangiectasia Hemorrhagic, Hereditary

Hht - [Hereditary Haemorrhagic Telangiectasia]

Osler Haemorrhagic Telangiectasia Syndrome

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta KCNK3 VGNC VGNC:106177
Canis familiaris KCNK3 VGNC VGNC:42275
Bos taurus KCNK3 VGNC VGNC:30473
Mus musculus KCNK3 MGD MGI:1100509
Rattus norvegicus KCNK3 RGD RGD:61997