2. Gene
  3. Fndc5 - fibronectin type III domain containing 5 Gene

Fndc5 - fibronectin type III domain containing 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PeP; Pxp; 1500001L03Rik

基因 ID: 384061 | 基因类型: protein coding

关于 Fndc5

功能概要

This gene encodes a type I transmembrane protein containing fibronectin type III repeat. The encoded transmembrane protein undergoes proteolytic processing to generate a soluble hormone named irisin that is secreted into the bloodstream. The expression of this gene followed by the secretion of irisin from skeletal muscle is induced by exercise. The ectopic expression of the encoded protein in mice causes an elevation of irisin in blood and improves metabolic health. [provided by RefSeq, Jul 2016]

Fndc5 基因产物(1)

mRNA Protein Name
NM_027402.4 NP_081678.1 fibronectin type III domain-containing protein 5 preproprotein
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of brown fat cell differentiation IDA
IDA: 通过直接分析推断
22237023 MGI
involved in response to muscle activity IDA
IDA: 通过直接分析推断
22237023 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12384288 MGI
located in extracellular region IDA
IDA: 通过直接分析推断
22237023 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
12384288 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

fibronectin type III domain-containing protein 5

fibronectin type III repeat-containing protein 2

peroxisomal protein

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05022 FNDC5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17253 Fndc5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23707 Fndc5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fndc5 NCBI NCBI:252995
Rattus norvegicus Fndc5 NCBI NCBI:260327
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