2. Gene
  3. MYCL - MYCL proto-oncogene, bHLH transcription factor Gene

MYCL - MYCL proto-oncogene, bHLH transcription factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MYCL 原癌基因、bHLH 转录因子

种属: Homo sapiens

同用名: LMYC; L-Myc; MYCL1; bHLHe38

基因 ID: 4610 | 基因类型: protein coding

关于 MYCL

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,895,428-39,901,917 (from NCBI)

This gene has 4 transcripts (splice variants), 270 orthologues, 2 paralogues and is associated with 63 phenotypes. Broad expression in skin (RPKM 18.4), pancreas (RPKM 11.3) and 17 other tissues.

功能概要

预测可实现 DNA 结合转录因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。预计参与 RNA 聚合酶 II 的转录调控。预计在内耳听觉受体细胞分化的调节上游或调节内起作用。位于染色体和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of inner ear auditory receptor cell differentiation. Located in chromosome and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MYCL 基因产物(3)

mRNA Protein Name
NM_001033081.3 NP_001028253.1 protein L-Myc isoform 1
NM_001033082.3 NP_001028254.2 protein L-Myc isoform 3
NM_005376.5 NP_005367.2 protein L-Myc isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYCL 蛋白结构

Myc_N

Myc_N: Myc amino-terminal region (28 - 167)

Myc_N

Myc_N: Myc amino-terminal region (187 - 251)

HLH

HLH: Helix-loop-helix DNA-binding domain (312 - 363)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
蛋白主名 其他名称

protein L-Myc

class E basic helix-loop-helix protein 38

关联疾病

疾病名称 别名
Apocrine Adenosis Of Breast

Apocrine Adenosis Of The Breast
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Lower Lip Cancer
Small Cell Cancer Of The Lung

Small Cell Lung Cancer

Small Cell Lung Carcinoma

Sclc

Small-Cell Cancer Of Lung

Lung Small Cell Carcinoma

Sclc1

Sccl

Cancer, Lung, Small Cell

Small Cell Carcinoma Of Lung

Carcinoma, Small Cell
Cerebral Primitive Neuroectodermal Tumor

Pnet Of Cerebrum
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08883 MYCL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20778 Mycl Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27292 Mycl Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MYCL VGNC VGNC:43529
Bos taurus MYCL VGNC VGNC:31787
Felis catus MYCL VGNC VGNC:80286
Rattus norvegicus MYCL RGD RGD:1588591
Macaca mulatta MYCL VGNC VGNC:100016
Mus musculus MYCL MGD MGI:96799
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