H2AB1 - H2A.B variant histone 1 Gene

中文名称：H2A.B 变体组蛋白 1

种属: Homo sapiens

同用名: H2A.B; H2AFB1; H2A.B.2; H2A.Bbd

关于 H2AB1

功能概要

组蛋白是基本的核蛋白，负责真核生物染色体纤维的核小体结构。核小体由大约 146 bp 的 DNA 组成，包裹在由四种核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一种成对组成的组蛋白八聚体周围。染色质纤维通过接头组蛋白 H1 与核小体之间的 DNA 相互作用进一步压缩，形成更高阶的染色质结构。该基因编码一种不依赖于复制的组蛋白，该组蛋白是组蛋白 H2A 家族的一员。该基因是在 X 染色体上重复三次的区域的一部分，一次在 F8 基因的内含子 22 中，两次靠近 Xq 端粒。该记录代表位于 F8 基因的内含子 22 中的最着丝粒拷贝。[RefSeq 提供，2015 年 10 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene. [provided by RefSeq, Oct 2015]