1. Gene
  2. RNFT1 - ring finger protein, transmembrane 1 Gene

RNFT1 - ring finger protein, transmembrane 1 Gene

中文名称:无名指蛋白,跨膜 1

种属: Homo sapiens

同用名: PTD016

基因 ID: 51136 | 基因类型: protein coding

关于 RNFT1

Cytogenetic location: 17q23.1 Genomic coordinates (GRCh38): 17:59,952,240-59,964,740 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and 1 paralogue. Broad expression in testis (RPKM 54.5), appendix (RPKM 8.9) and 22 other tissues.

功能概要

启用泛素结合活性和泛素蛋白连接酶活性。参与 ERAD 通路和蛋白质自身泛素化的正向调节。位于内质网。 [由基因组资源联盟提供,2022 年 4 月]

Enables ubiquitin binding activity and ubiquitin protein Ligase activity. Involved in positive regulation of ERAD pathway and protein autoubiquitination. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

RNFT1 基因产物(1)

mRNA Protein Name
NM_016125.4 NP_057209.3 E3 ubiquitin-protein ligase RNFT1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ubiquitin binding IDA
IDA: 通过直接分析推断
27485036 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
27485036 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of ERAD pathway IMP
IMP: 通过突变表型推断
27485036 GOA
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
27485036 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
27485036 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RNFT1 蛋白结构

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (372 - 418)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 435 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNFT1

RING finger and transmembrane domain-containing protein 1

关联疾病

疾病名称 别名
Papillary Cystadenocarcinoma

Cystadenocarcinoma, Papillary

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus RNFT1 VGNC VGNC:34074
Mus musculus RNFT1 MGD MGI:1924142
Canis familiaris RNFT1 VGNC VGNC:45677
Felis catus RNFT1 VGNC VGNC:64707
Rattus norvegicus RNFT1 RGD RGD:1562411
Macaca mulatta RNFT1 VGNC VGNC:76865