2. Gene
  3. FBXO40 - F-box protein 40 Gene

FBXO40 - F-box protein 40 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：F-box 蛋白 40

种属: Homo sapiens

同用名: FBX40

基因 ID: 51725 | 基因类型: protein coding

关于 FBXO40

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:121,593,379-121,630,295 (from NCBI)

This gene has 1 transcript (splice variant), 308 orthologues and 1 paralogue. Restricted expression toward heart (RPKM 38.1).

功能概要

F-box 蛋白家族的成员，例如 FBXO40，以大约 40 个氨基酸的 F-box 基序为特征。由 SKP1 (MIM 601434) 、cullin (参见 CUL1；MIM 603134) 和 F-box 蛋白形成的 SCF 复合物充当蛋白质-泛素连接酶。 F-box 蛋白通过 F-box 与 SKP1 相互作用，并且它们通过其他蛋白质相互作用域与泛素化目标相互作用 (Jin 等人，2004 [PubMed 15520277]) 。[OMIM 提供，2008 年 3 月]

Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXO40 基因产物(1)

mRNA Protein Name
NM_016298.4 NP_057382.2 F-box only protein 40
蛋白主名 其他名称

F-box only protein 40

muscle disease-related protein

关联疾病

疾病名称 别名
Limb-Girdle Muscular Dystrophy

Lgmd

Limb Girdle Muscular Dystrophy

Muscular Dystrophies, Limb-Girdle

Erb'S Muscular Dystrophy

Leyden-Mbius Muscular Dystrophy

Limb-Girdle Syndrome

Myopathic Limb-Girdle Syndrome

Limb Girdle

Muscular Dystrophy Limb-Girdle

Dystrophy, Muscular, Limb-Girdle

Lgmd - [Limb-Girdle Muscular Dystrophy]

Limb Girdle Muscle Dystrophy

Limb-Girdle Myopathy
Juvenile-Onset Parkinson'S Disease

Juvenile-Onset Parkinson Disease
Childhood Disintegrative Disease

Childhood Disintegrative Disorder

Disintegrative Psychosis

Heller'S Syndrome

Symbiotic Psychosis

Dementia Infantilis

Heller Syndrome

Shared Paranoid Disorder
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04807 FBXO40 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FBXO40 RGD RGD:1309781
Canis familiaris FBXO40 VGNC VGNC:40780
Felis catus FBXO40 VGNC VGNC:62192
Macaca mulatta FBXO40 VGNC VGNC:72601
Mus musculus FBXO40 MGD MGI:2443753
Bos taurus FBXO40 VGNC VGNC:28911
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