BRWD1 - bromodomain and WD repeat domain containing 1 Gene

中文名称：含溴域和 WD 重复域 1

种属: Homo sapiens

同用名: N143; WDR9; WRD9; DCAF19; C21orf107

关于 BRWD1

功能概要

该基因编码 WD 重复蛋白家族的一个成员。 WD 重复是大约 40 个氨基酸的最小保守区域，通常由 gly-his 和 trp-asp (GH-WD) 残基括起来，这可能促进异三聚体或多蛋白复合物的形成。该家族的成员参与多种细胞过程，包括细胞周期进程、信号转导、细胞凋亡和基因调控。该蛋白质包含 2 个溴结构域和多个 WD 重复序列。该基因位于 21 号染色体上的唐氏综合症区域 2 内。该基因的选择性剪接会产生编码不同亚型的多个转录变体。在小鼠中，该基因编码一种核蛋白，该蛋白具有一个含有聚谷氨酰胺的区域，该区域充当转录激活域，可调节染色质重塑并与 SWI/SNF 染色质重塑复合物的一个成分相关。[RefSeq 提供，2011 年 6 月]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]