1. Gene
  2. RC3H2 - ring finger and CCCH-type domains 2 Gene

RC3H2 - ring finger and CCCH-type domains 2 Gene

中文名称:无名指和 CCCH 类型域 2

种属: Homo sapiens

同用名: MNAB; RNF164

基因 ID: 54542 | 基因类型: protein coding

关于 RC3H2

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:122,844,556-122,905,359 (from NCBI)

This gene has 10 transcripts (splice variants), 206 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 7.8), testis (RPKM 7.6) and 25 other tissues.

功能概要

启用核酸结合活性和泛素蛋白连接酶活性。参与蛋白质多聚泛素化。位于细胞表面;细胞内膜结合细胞器;和膜。 [由基因组资源联盟提供,2022 年 4 月]

Enables nucleic acid binding activity and ubiquitin protein Ligase activity. Involved in protein polyubiquitination. Located in cell surface; intracellular membrane-bounded organelle; and membrane. [provided by Alliance of Genome Resources, Apr 2022]

RC3H2 基因产物(6)

mRNA Protein Name
NM_001100588.3 NP_001094058.1 roquin-2 isoform 1
NM_001354478.2 NP_001341407.1 roquin-2 isoform 3
NM_001354479.2 NP_001341408.1 roquin-2 isoform 4
NM_001354482.2 NP_001341411.1 roquin-2 isoform 5
NM_001354486.2 NP_001341415.1 roquin-2 isoform 6
NM_018835.5 NP_061323.2 roquin-2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
10938276 GOA
enables RNA stem-loop binding IDA
IDA: 通过直接分析推断
26249698 GOA
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
26489670 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
24448648 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
26489670 GOA
involved in protein polyubiquitination IMP
IMP: 通过突变表型推断
24448648 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
10938276 GOA
located in membrane IDA
IDA: 通过直接分析推断
10938276 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RC3H2 蛋白结构

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (411 - 437)

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  • 1191 a.a.
蛋白主名 其他名称

roquin-2

RING finger protein 164

直系同源

种属 基因名 来源 基因 ID
Felis catus RC3H2 VGNC VGNC:64541
Bos taurus RC3H2 VGNC VGNC:33819
Macaca mulatta RC3H2 VGNC VGNC:76799
Mus musculus RC3H2 MGD MGI:2442789
Rattus norvegicus RC3H2 RGD RGD:1304833