1. Gene
  2. KCNK13 - potassium two pore domain channel subfamily K member 13 Gene

KCNK13 - potassium two pore domain channel subfamily K member 13 Gene

中文名称:钾二孔域通道亚科 K 成员 13

种属: Homo sapiens

同用名: THIK1; THIK-1; K2p13.1

基因 ID: 56659 | 基因类型: protein coding

关于 KCNK13

Cytogenetic location: 14q32.11 Genomic coordinates (GRCh38): 14:90,061,994-90,185,853 (from NCBI)

This gene has 1 transcript (splice variant), 249 orthologues and 14 paralogues. Biased expression in testis (RPKM 6.7), kidney (RPKM 2.6) and 6 other tissues.

功能概要

从功能和结构的角度来看,钾通道代表了最复杂的一类电压门控离子通道。它们的不同功能包括调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质转运、平滑肌收缩和细胞体积。该基因编码含有两个成孔结构域的钾通道。这种蛋白质是一个开放通道,可以被花生四烯酸刺激并被麻醉剂氟烷抑制。[RefSeq 提供,2013 年 7 月]

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a Potassium Channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]

KCNK13 基因产物(1)

mRNA Protein Name
NM_022054.4 NP_071337.2 potassium channel subfamily K member 13

KCNK13 蛋白结构

Ion_trans_2

Ion_trans_2: Ion channel (93 - 150)

Ion_trans_2

Ion_trans_2: Ion channel (198 - 283)

  • 0
  • 100
  • 200
  • 300
  • 408 a.a.
蛋白主名 其他名称

potassium channel subfamily K member 13

K2P13.1 potassium channel

关联疾病

疾病名称 别名
Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome

BIBARS

Mental Retardation With Hypotonia And Facial Dysmorphism

Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome

Kcnk9 Imprinting Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus KCNK13 VGNC VGNC:104479
Macaca mulatta KCNK13 VGNC VGNC:82167
Bos taurus KCNK13 VGNC VGNC:106791
Rattus norvegicus KCNK13 RGD RGD:68941
Mus musculus KCNK13 MGD MGI:2384976
Canis familiaris KCNK13 VGNC VGNC:53499