NCOA5 - nuclear receptor coactivator 5 Gene

中文名称：核受体共激活因子 5

种属: Homo sapiens

同用名: CIA; bA465L10.6

关于 NCOA5

功能概要

该基因编码 alpha 和 beta 雌激素受体以及孤儿核受体 NR1D2 的共同调节因子。该蛋白质定位于细胞核，被认为具有共激活因子和辅抑制因子功能。它与核受体的相互作用独立于受体上的 AF2 结构域，众所周知，AF2 结构域调节与其他辅助受体的相互作用。已发现该基因的几种可变剪接转录物变体。[RefSeq 提供，2017 年 1 月]

This gene encodes a coregulator for the alpha and beta estrogen receptors and the Orphan Nuclear Receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with Other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]