2. Gene
  3. ZFYVE28 - zinc finger FYVE-type containing 28 Gene

ZFYVE28 - zinc finger FYVE-type containing 28 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指 FYVE 型 28

种属: Homo sapiens

同用名: LST2; LYST2; lst-2

基因 ID: 57732 | 基因类型: protein coding

关于 ZFYVE28

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,269,597-2,418,645 (from NCBI)

This gene has 11 transcripts (splice variants), 215 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 1.1), brain (RPKM 1.1) and 25 other tissues.

功能概要

启用磷脂酰肌醇-3-磷酸结合活性。参与表皮生长因子激活受体活性的负调节。位于胞质溶胶和早期内体膜中。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphatidylinositol-3-phosphate binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity. Located in cytosol and early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZFYVE28 基因产物(6)

mRNA Protein Name
NM_001172656.2 NP_001166127.1 lateral signaling target protein 2 homolog isoform 3
NM_001172657.2 NP_001166128.1 lateral signaling target protein 2 homolog isoform 4
NM_001172658.3 NP_001166129.1 lateral signaling target protein 2 homolog isoform 5
NM_001172659.2 NP_001166130.1 lateral signaling target protein 2 homolog isoform 1
NM_001172660.3 NP_001166131.1 lateral signaling target protein 2 homolog isoform 6
NM_020972.3 NP_066023.2 lateral signaling target protein 2 homolog isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol-3-phosphate binding IDA
IDA: 通过直接分析推断
19460345 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19460345 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
19460345 GOA
involved in negative regulation of epidermal growth factor-activated receptor activity IMP
IMP: 通过突变表型推断
19460345 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
19460345 GOA
located in early endosome membrane IDA
IDA: 通过直接分析推断
19460345 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFYVE28 蛋白结构

FYVE

FYVE: FYVE zinc finger (813 - 873)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 887 a.a.
蛋白主名 其他名称

lateral signaling target protein 2 homolog

hLst2

关联疾病

疾病名称 别名
Adiaspiromycosis
Anti-Basement Membrane Glomerulonephritis

Anti-Gbm Glomerulonephritis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16061 ZFYVE28 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZFYVE28 MGD MGI:2684992
Macaca mulatta ZFYVE28 VGNC VGNC:107211
Bos taurus ZFYVE28 VGNC VGNC:37178
Canis familiaris ZFYVE28 VGNC VGNC:53255
Felis catus ZFYVE28 VGNC VGNC:107480
Rattus norvegicus ZFYVE28 RGD RGD:1310151
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