SELPLG - selectin P ligand Gene

中文名称：选择素 P 配体

种属: Homo sapiens

同用名: CLA; CD162; PSGL1; PSGL-1

基因 ID: 6404 | 基因类型: protein coding

关于 SELPLG

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,621,895-108,633,894 (from NCBI)

This gene has 3 transcripts (splice variants) and 72 orthologues. Broad expression in spleen (RPKM 29.0), lymph node (RPKM 26.4) and 22 other tissues.

功能概要

该基因编码一种糖蛋白，它作为细胞粘附分子 P-、E- 和 L- 选择素的高亲和力反受体，在骨髓细胞和受刺激的 T 淋巴细胞上表达。因此，这种蛋白质通过将白细胞束缚到活化的血小板或表达选择素的内皮细胞，在炎症期间的白细胞运输中发挥关键作用。这种蛋白质需要两个翻译后修饰，即酪氨酸硫酸化和向其 O-连接的聚糖添加唾液酸 Lewis x 四糖 (sLex) ，以实现其高亲和力结合活性。该基因的异常表达和该基因的多态性与先天性和适应性免疫反应的缺陷有关。交替剪接导致多个转录变体。[RefSeq 提供，2011 年 4 月]

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- Selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

SELPLG 基因产物(2)

mRNA	Protein	Name
NM_001206609.2	NP_001193538.1	P-selectin glycoprotein ligand 1 isoform 1 precursor
NM_003006.4	NP_002997.2	P-selectin glycoprotein ligand 1 isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11081633	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within cellular response to interleukin-6	IDA IDA: 通过直接分析推断	9486531	GOA
involved in leukocyte migration	IDA IDA: 通过直接分析推断	25425738	GOA
involved in leukocyte tethering or rolling	IDA IDA: 通过直接分析推断	25425738	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	21696602	GOA
located in plasma membrane raft	IDA IDA: 通过直接分析推断	25425738	GOA
located in uropod	IDA IDA: 通过直接分析推断	21696602	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

P-selectin glycoprotein ligand 1

cutaneous lymphocyte-associated associated antigen

SELPLG 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SELPLG	Q14242	SELP	Homo sapiens	P16109	SPR	19118202
种属内	SELPLG	Q14242	SNX20	Homo sapiens	Q7Z614	Peptide Array	18196517
种属内	SELPLG	Q14242	SNX20	Homo sapiens	Q7Z614	Y2H	18196517
种属内	SELPLG	Q14242	SNX20	Homo sapiens	Q7Z614	Anti Bait CoIP	18196517

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SELPLG 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72485	CD162/PSGL-1 Protein, Human (HEK293, hFc)	Q14242 (Q42-G295)	≥95%
HY-P77162	CD162/PSGL-1 Protein, Human (HEK293, His-Fc)	AAC50061.1(L18-V295)	≥95%
HY-P77163	CD162/PSGL-1 Protein, Human (HEK293, His)	Q14242 (M1-G295)	≥95%
HY-P77164	CD162/PSGL-1 Protein, Human (HEK293, mFc)	AAC50061.1(L18-V295)	≥95%
HY-P78819	CD162/PSGL-1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q14242-1 (Q42-C320)	≥95%

SELPLG 抗体

目录号	产品名	应用	反应物种
HY-P81711	PSGL1 Antibody (YA1456)	WB, IHC-P, ICC/IF, IP	Human
HY-P84565	CD162 Antibody (YA4262)	IHC-P, FC, ELISA	Human
HY-P84970	CD162 Antibody (YA4662)

关联疾病

疾病名称

别名

Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis	Hge
Human Ehrlichial Infection, Human Granulocytic Type	Human Anaplasmosis Due To Anaplasma Phagocytophilum

Ehrlichiosis

Human Ehrlichiosis	He
Hey

Thrombosis

Thrombosis Of Blood Vessel

Cerebrovascular Disease

Cerebrovascular Disorder	Cerebrovascular Accident
Cerebrovascular Disorders	Cva
Stroke

Endocervicitis

Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency	Leukocyte Adhesion Deficiency 1
LAD1	Lad
Lymphocyte Function-Associated Antigen 1 Immunodeficiency	Leukocyte Adhesion Deficiency Type I
Leukocyte Adhesion Deficiency Type 1	Linear Iga Bullous Dermatosis
Linear Iga Dermatosis	Leukocyte-Adhesion Deficiency Syndrome
Lfa1 Immunodeficiency	Congenital Leukocyte Adherence Deficiency
Lad-I	Linear Iga Disease
Leukocyte Adhesion Deficiency Syndrome	Lad 1
Lfa 1 Immunodeficiency	Linear Immunoglobulin A Dermatosis
Leucocyte Adhesion Deficiency Type 1	Leukocyte Adhesion Molecule Deficiency Type 1

Colon Carcinoma In Situ

Carcinoma In Situ Of Colon	Stage 0 Colonic Carcinoma
Stage 0 Carcinoma Of Colon	Intraepithelial Neoplasia Of Colon, High Grade
Carcinoma In Situ Of Cecum	Carcinoma In Situ Of Hepatic Flexure
Carcinoma In Situ Of Ileocecal Valve	Carcinoma In Situ Of Hepatic Flexure Of Colon

Intestine Carcinoma In Situ

Acute Flaccid Myelitis

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Aseptic Meningitis

Acute Aseptic Meningitis	Meningitis Aseptic
Meningitis, Aseptic

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12648	SELPLG Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS18203	Selplg Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS24679	Selplg Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SELPLG	VGNC	VGNC:107723
Macaca mulatta	SELPLG	VGNC	VGNC:77158
Rattus norvegicus	SELPLG	RGD	RGD:1307971
Mus musculus	SELPLG	MGD	MGI:106689
Canis familiaris	SELPLG	VGNC	VGNC:45986
Bos taurus	SELPLG	VGNC	VGNC:34425
Macaca fascicularis	SELPLG	NCBI	NCBI:102142477
Others	SELPLG	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SELPLG - selectin P ligand Gene

关于 SELPLG

功能概要

SELPLG 基因产物(2)

SELPLG 蛋白互作信息

重组 SELPLG 蛋白

SELPLG 抗体

关联疾病

直系同源

热门区域

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SELPLG - selectin P ligand Gene

关于 SELPLG

功能概要

SELPLG 基因产物(2)

SELPLG 蛋白互作信息

重组 SELPLG 蛋白

SELPLG 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z