2. Gene
  3. TARBP1 - TAR (HIV-1) RNA binding protein 1 Gene

TARBP1 - TAR (HIV-1) RNA binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TAR (HIV-1) RNA 结合蛋白 1

种属: Homo sapiens

同用名: TRM3; TRMT3; TRP185; TRP-185

基因 ID: 6894 | 基因类型: protein coding

关于 TARBP1

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:234,391,313-234,479,179 (from NCBI)

This gene has 9 transcripts (splice variants), 200 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 7.3), prostate (RPKM 6.2) and 25 other tissues.

功能概要

HIV-1 是获得性免疫缺陷综合症 (AIDS) 的病原体，它包含一个 RNA 基因组，可在复制周期中产生染色体整合的 DNA。反式激活因子 Tat 对 HIV-1 基因表达的激活依赖于位于转录起始位点下游的 RNA 调节元件 (TAR) 。该元件形成稳定的茎环结构，可被该基因编码的蛋白质或 RNA 聚合酶 II 结合。这种蛋白质可能在转录延伸过程中使 RNA 聚合酶 II 从 TAR 脱离。可能存在该基因的可变剪接转录本，但尚未确定其全长性质。[RefSeq 提供，2008 年 7 月]

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

TARBP1 基因产物(1)

mRNA Protein Name
NM_005646.4 NP_005637.3 probable methyltransferase TARBP1

TARBP1 蛋白结构

SpoU_methylase

SpoU_methylase: SpoU rRNA Methylase family (1464 - 1605)

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  • 1621 a.a.
蛋白主名 其他名称

probable methyltransferase TARBP1

TAR (HIV) RNA-binding protein 1

关联疾病

疾病名称 别名
Fibroepithelial Basal Cell Carcinoma

Fibroepithelioma Of Pinkus

Fibroepithelioma Of Pinkus Type

Pinkus Tumor
Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14206 TARBP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TARBP1 MGD MGI:4936930
Rattus norvegicus TARBP1 RGD RGD:1589526
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